Literature DB >> 17784775

Synthesis of polysubstituted imidazo[1,2-a]pyridines via microwave-assisted one-pot cyclization/Suzuki coupling/palladium-catalyzed heteroarylation.

Jamal Koubachi1, Saïd El Kazzouli, Sabine Berteina-Raboin, Abderrahim Mouaddib, Gérald Guillaumet.   

Abstract

A new and efficient method for the synthesis of 2,3,6-trisubstituted imidazo[1,2-a]pyridine derivatives using a microwave-assisted one-pot, two-step Suzuki/heteroarylation or one-pot, three-step cyclization/Suzuki/heteroarylation was developed. Polysubstituted compounds are obtained in good yield from 2-amino-5-halogenopyridines, 2-halogenocarbonyl derivatives, boronic acids, and heteroaryl bromides.

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Year:  2007        PMID： 17784775     DOI： 10.1021/jo0712603

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  6 in total

Review 1.  Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

Authors:  C Oliver Kappe; Doris Dallinger
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

Review 2.  Recent advances on the transition-metal-catalyzed synthesis of imidazopyridines: an updated coverage.

Authors:  Gagandeep Kour Reen; Ashok Kumar; Pratibha Sharma
Journal:  Beilstein J Org Chem       Date:  2019-07-19       Impact factor: 2.883

3.  Fluorescent property of 3-hydroxymethyl imidazo[1,2-a]pyridine and pyrimidine derivatives.

Authors:  Stephania Velázquez-Olvera; Héctor Salgado-Zamora; Manuel Velázquez-Ponce; Elena Campos-Aldrete; Alicia Reyes-Arellano; Cuauhtémoc Pérez-González
Journal:  Chem Cent J       Date:  2012-08-07       Impact factor: 4.215

4.  Facile synthesis of 3-substituted imidazo[1,2-a]pyridines through formimidamide chemistry.

Authors:  Rasapalli Sivappa; Vamshikrishna Reddy Sammeta; Yanchang Huang; James A Golen; Sergey N Savinov
Journal:  RSC Adv       Date:  2019-09-19       Impact factor: 4.036

5.  Intramolecular H-bonding interaction in angular 3-π-EWG substituted imidazo[1,2-a]pyridines contributes to conformational preference.

Authors:  Manuel Velázquez-Ponce; Héctor Salgado-Zamora; Hugo A Jiménez-Vázquez; Maria Elena Campos-Aldrete; Rogelio Jiménez; Humberto Cervantes; Taibi Ben Hadda
Journal:  Chem Cent J       Date:  2013-01-31       Impact factor: 4.215

6.  First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules.

Authors:  Mohammed Aounzou; Joana F Campos; Mohammed Loubidi; Sabine Berteina-Raboin
Journal:  Molecules       Date:  2018-05-11       Impact factor: 4.411
  6 in total

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