Literature DB >> 17780007

Myotonic response induced by inhibitors of cholesterol biosynthesis.

N Winer, D M Klachko, R D Baer, P L Langley, T W Burns.   

Abstract

Steroid inhibitors of cholesterogenesis containing nitrogen-substituted side chains induced electromyographic myotonia in rats. Cholesterol reduction or desmosterol accumulation, per se, did not cause myotonia, and cholestrol feeding prevented drug-induced myotonia. Desmosterol accumulation in combination with a specific drug effect may cause the observed myotonia.

Entities:  

Year:  1966        PMID： 17780007     DOI： 10.1126/science.153.3733.312

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  11 in total

1.  The ATPases of the sarcolemma from skeletal muscle in experimental myotonia.

Authors:  D Seiler
Journal:  Experientia       Date:  1971-10-15

2.  A special form of automaticity in the isolated papillary muscle of rats with experimental myotonia.

Authors:  R Bodem; Y Mattern; E Kuhn
Journal:  Klin Wochenschr       Date:  1973-09-01

3.  Experimental myotonia in mammalian skeletal muscle: changes in membrane properties.

Authors:  R Rüdel; J Senges
Journal:  Pflugers Arch       Date:  1972       Impact factor: 3.657

4.  Myotonia. A review of its clinical implications.

Authors:  G P Bhatt; N Vijayan; P M Dreyfus
Journal:  Calif Med       Date:  1971-02

Review 5.  Myotonia--a different point of view.

Authors:  W K Engel
Journal:  Calif Med       Date:  1971-02

6.  Role of lipids in the Neurospora crassa membrane: IV. Biochemical and electrophysiological changes caused by growth on phytanic acid.

Authors:  K J Friedman; D Glick
Journal:  J Membr Biol       Date:  1982       Impact factor: 1.843

7.  Fast to slow transition induced by experimental myotonia in rat EDL muscle.

Authors:  G Salviati; E Biasia; R Betto; D Danieli Betto
Journal:  Pflugers Arch       Date:  1986-03       Impact factor: 3.657

8.  Cholesterol in muscle membranes.

Authors:  D R Headon; E J Barrett; N M Joyce; J O'Flaherty
Journal:  Mol Cell Biochem       Date:  1977-10-07       Impact factor: 3.396

9.  Alteration of developing and adult rat muscle membranes by zuclomiphene and other hypocholesterolemic agents.

Authors:  R B Ramsey; J D McGarry; V W Fischer; H B Sarnat
Journal:  Acta Neuropathol       Date:  1978-10-13       Impact factor: 17.088

10.  Movement of plasma-membrane sterols to the endoplasmic reticulum in cultured cells.

Authors:  J P Slotte; E L Bierman
Journal:  Biochem J       Date:  1987-11-15       Impact factor: 3.857
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