Analysis of hydrodynamic data for denatured globular proteins in terms of the wormlike cylinder model.

Hydrodynamic data, i.e. intrinsic viscosity and sedimentation coefficient, for denatured globular proteins in 6 M guanidinium chloride have been re-analysed in terms of the Yamakawa-Fujii theory of the wormlike cylinder model. Molecular parameters thus obtained ((mean value of R2 0/M) infinity, the Kuhn statistical segment length and the molecular weight per unit contour length) are in better agreement with the values obtained theoretically or by other methods than those evaluated on the basis of the model of non-draining random coil.