| Literature DB >> 17769215 |
J Jaenike, D A Grimaldi, A E Sluder, A L Greenleaf.
Abstract
Six species of Drosophila were tested for tolerance to the mushroom toxin alpha-amanitin, a potent inhibitor of RNA polymerase II. Three nonmycophagous species-D. melanogaster, D. immigrans, and D. pseudoobscura-showed very low survival and long development times in the presence of amanitin. Three mycophagous species-D. putrida, D. recens, and D. tripunctata-showed little or no sensitivity. Analysis in vitro indicated that this tolerance is not based on alteration of the molecular structure of RNA polymerase II.Entities:
Year: 1983 PMID: 17769215 DOI: 10.1126/science.221.4606.165
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728