Literature DB >> 1776875

Cellular uptake of phosphonylmethoxyalkylpurine derivatives.

G Palú1, S Stefanelli, M Rassu, C Parolin, J Balzarini, E De Clercq.   

Abstract

The cellular uptake of the phosphonylmethoxyalkylpurine derivatives HPMPA and PMEA has been studied in H9 cells. The two compounds exhibited an identical pattern of permeation in this cell line. Uptake did not occur via the nucleoside transport system, but through a different mechanism which, for its slow kinetics and temperature-dependence, is compatible with an endocytosis-like process. The amount of cell-associated drug increased up to one hour post-incubation.

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Year:  1991        PMID： 1776875     DOI： 10.1016/0166-3542(91)90063-w

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  17 in total

1.  Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer.

Authors:  Chin-chung Lin; Che Fang; Salete Benetton; Gui-fen Xu; Li-Tain Yeh
Journal:  Antimicrob Agents Chemother       Date:  2006-09       Impact factor: 5.191

2.  Single-dose pharmacokinetics and metabolism of [14C]remofovir in rats and cynomolgus monkeys.

Authors:  Chin-Chung Lin; Christine Xu; Nanqun Zhu; David Lourenco; Li-Tain Yeh
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

3.  Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks.

Authors:  J M Cullen; D H Li; C Brown; E J Eisenberg; K C Cundy; J Wolfe; J Toole; C Gibbs
Journal:  Antimicrob Agents Chemother       Date:  2001-10       Impact factor: 5.191

Review 4.  Adefovir dipivoxil.

Authors:  S Noble; K L Goa
Journal:  Drugs       Date:  1999-09       Impact factor: 9.546

5.  Differential Mechanisms of Tenofovir and Tenofovir Disoproxil Fumarate Cellular Transport and Implications for Topical Preexposure Prophylaxis.

Authors:  Ekaterina Taneva; Kerry Crooker; Sung Hyun Park; Jonathan T Su; Adina Ott; Natalia Cheshenko; Igal Szleifer; Patrick F Kiser; Bruce Frank; Pedro M M Mesquita; Betsy C Herold
Journal:  Antimicrob Agents Chemother       Date:  2015-12-28       Impact factor: 5.191

6.  Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.

Authors:  L Naesens; J Balzarini; N Bischofberger; E De Clercq
Journal:  Antimicrob Agents Chemother       Date:  1996-01       Impact factor: 5.191

Review 7.  Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives.

Authors:  J Balzarini
Journal:  Pharm World Sci       Date:  1994-04-15

8.  Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated.

Authors:  T Cihlár; I Rosenberg; I Votruba; A Holý
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

9.  Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art.

Authors:  Karl Y Hostetler
Journal:  Antiviral Res       Date:  2009-05       Impact factor: 5.970

10.  Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates.

Authors:  R V Srinivas; B L Robbins; M C Connelly; Y F Gong; N Bischofberger; A Fridland
Journal:  Antimicrob Agents Chemother       Date:  1993-10       Impact factor: 5.191
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