OBJECTIVES: Vitamin D deficiency (VDD) is common in immigrant children with increased skin pigmentation living in higher latitudes. We assessed the pattern of and risk factors for VDD in immigrant East African children living in Melbourne (latitude 37 degrees 49' South). STUDY DESIGN: A prospective survey of 232 East African children attending a clinic in Melbourne. Data were collected by questionnaire, medical assessment and laboratory tests. RESULTS: Low 25-hydroxyvitamin D (25-OHD) levels (<50 nmol/l) occurred in 87% of children, and VDD (25-OHD <25 nmol/l) in 44%. Risk factors included age <5 years, female gender, increased time in Australia, decreased daylight exposure and winter/spring season. Anaemia (20%), vitamin A deficiency (20%) and iron deficiency (19%) were also identified. CONCLUSIONS: Asymptomatic VDD is common in East African immigrant children residing at a temperate latitude. Risk factors for VDD limit endogenous vitamin D production. Screening of immigrant children with increased skin pigmentation for VDD, anaemia, iron and vitamin A deficiency is appropriate. VDD in adolescent females identifies an increased risk of future infants with VDD.
OBJECTIVES:Vitamin D deficiency (VDD) is common in immigrant children with increased skin pigmentation living in higher latitudes. We assessed the pattern of and risk factors for VDD in immigrant East African children living in Melbourne (latitude 37 degrees 49' South). STUDY DESIGN: A prospective survey of 232 East African children attending a clinic in Melbourne. Data were collected by questionnaire, medical assessment and laboratory tests. RESULTS: Low 25-hydroxyvitamin D (25-OHD) levels (<50 nmol/l) occurred in 87% of children, and VDD (25-OHD <25 nmol/l) in 44%. Risk factors included age <5 years, female gender, increased time in Australia, decreased daylight exposure and winter/spring season. Anaemia (20%), vitamin A deficiency (20%) and iron deficiency (19%) were also identified. CONCLUSIONS: Asymptomatic VDD is common in East African immigrant children residing at a temperate latitude. Risk factors for VDD limit endogenous vitamin D production. Screening of immigrant children with increased skin pigmentation for VDD, anaemia, iron and vitamin A deficiency is appropriate. VDD in adolescent females identifies an increased risk of future infants with VDD.
Authors: V Matkovic; T Jelic; G M Wardlaw; J Z Ilich; P K Goel; J K Wright; M B Andon; K T Smith; R P Heaney Journal: J Clin Invest Date: 1994-02 Impact factor: 14.808
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Authors: Laura Toxqui; Ana M Pérez-Granados; Ruth Blanco-Rojo; Ione Wright; Concepción de la Piedra; M Pilar Vaquero Journal: Eur J Nutr Date: 2013-06-16 Impact factor: 5.614
Authors: Sarah Cherian; David A Forbes; Angus G Cook; Frank M Sanfilippo; Erwin H Kemna; Dorine W Swinkels; David P Burgner Journal: PLoS One Date: 2008-12-24 Impact factor: 3.240