| Literature DB >> 17768125 |
Huiling Shen, Wenlin Xu, Zhaoyang Wu, Huarong Tang, Yanyan Xie, Ximing Zhong.
Abstract
We have shown that inhibition of WT1/+17AA protein expression following transfection with a vector-based small interfering RNA expression construct in K562 cell lines, leads to a decrease in MDR1 and P-glycoprotein levels, accumulation of Rh123, and enhancement of the doxorubicin cytotoxicity. Our findings suggest that WT1/+17AA exerts its oncogenic function by modulating multidrug resistance in leukemia cells.Entities:
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Year: 2007 PMID： 17768125 DOI： 10.3324/haematol.11010
Source DB: PubMed Journal: Haematologica ISSN： 0390-6078 Impact factor: 9.941