| Literature DB >> 17768123 |
Prasenjit Guchhait, Swapan K Dasgupta, Anhquyen Le, Sarvari Yellapragada, José A López, Perumal Thiagarajan.
Abstract
Increased exposure of sickle red blood cells to phosphatidylserine promotes its adhesion to the endothelium. A monoclonal antibody to lactadherin, a phosphatidylserine binding protein, inhibits sickle cell adhesion to histamine-stimulated endothelial cells in flowing blood. Added lactadherin enhances the adhesion via the integrin alphaVbeta3. These results indicate that lactadherin can mediate phosphatidylserine-expressing sickle cell adhesion to the endothelium.Entities:
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Year: 2007 PMID: 17768123 DOI: 10.3324/haematol.11379
Source DB: PubMed Journal: Haematologica ISSN: 0390-6078 Impact factor: 9.941