| Literature DB >> 17768048 |
Nigel Ribeiro1, Helena Tabaka, Jean Peluso, Ludivine Fetzer, Can Nebigil, Serge Dumont, Christian D Muller, Laurent Désaubry.
Abstract
We synthesized 3-O-methylviridicatin and several analogues of this fungal metabolite. We showed that replacement of the methoxy moiety by a thiomethyl enhanced dramatically its ability to inhibit TNF-alpha secretion. These results strongly suggest that 4-phenyl-3-methylthioquinolinone may provide the basis for the development of new anti-inflammatory agents.Entities:
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Year: 2007 PMID： 17768048 DOI： 10.1016/j.bmcl.2007.08.036
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823