| Literature DB >> 17767900 |
Abstract
Global reduction in insulin signaling has been linked to extended life span in a range of organisms. New work on mice with brain-specific or whole-body reductions in insulin receptor substrate 2 (IRS2) (Taguchi et al., 2007) points to a role for insulin/IGF-1 signaling in the central control of mammalian aging.Entities:
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Year: 2007 PMID： 17767900 DOI： 10.1016/j.cmet.2007.08.007
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287