OBJECTIVES: Intraventricular catheters impregnated with silver nanoparticles are developed to reduce catheter-associated infections in cerebrospinal fluid (CSF) drainages. Silver released from these new catheters should have an anti-microbacterial effect. This study examines the silver ion release and a potential effect of bacterial growth in an in vitro experiment. METHODS: Seven original silver-coated ventricle catheters were rinsed thoroughly with an artificial CSF for 6 days. The collecting containers were replaced every 24 hours. In these samples, ion concentrations of silver were determined via trace analysis through atomic absorption spectroscopy. Furthermore, a bacterial growth was conducted on silver-impregnated and non-impregnated catheters. RESULTS: In none of the samples, a concentration of silver ions could be detected. For Staphylococcus aureus, a slightly decreased bacterial growth could be observed with silver-impregnated catheters. DISCUSSION: There is no risk of a toxic effect due to silver release into the CSF. However, the in vivo antibacterial effect has to be further investigated. We recommend clinical trials to prove the oligodynamic and anti-microbacterial effects of silver-impregnated ventricular catheters.
OBJECTIVES: Intraventricular catheters impregnated with silver nanoparticles are developed to reduce catheter-associated infections in cerebrospinal fluid (CSF) drainages. Silver released from these new catheters should have an anti-microbacterial effect. This study examines the silver ion release and a potential effect of bacterial growth in an in vitro experiment. METHODS: Seven original silver-coated ventricle catheters were rinsed thoroughly with an artificial CSF for 6 days. The collecting containers were replaced every 24 hours. In these samples, ion concentrations of silver were determined via trace analysis through atomic absorption spectroscopy. Furthermore, a bacterial growth was conducted on silver-impregnated and non-impregnated catheters. RESULTS: In none of the samples, a concentration of silver ions could be detected. For Staphylococcus aureus, a slightly decreased bacterial growth could be observed with silver-impregnated catheters. DISCUSSION: There is no risk of a toxic effect due to silver release into the CSF. However, the in vivo antibacterial effect has to be further investigated. We recommend clinical trials to prove the oligodynamic and anti-microbacterial effects of silver-impregnated ventricular catheters.
Authors: Myriam K S Ballo; Sami Rtimi; César Pulgarin; Nancy Hopf; Aurélie Berthet; John Kiwi; Philippe Moreillon; José M Entenza; Alain Bizzini Journal: Antimicrob Agents Chemother Date: 2016-08-22 Impact factor: 5.191
Authors: Reham M Goda; Ahmed M El-Baz; Eman M Khalaf; Nada K Alharbi; Tarek A Elkhooly; Mohamed M Shohayeb Journal: Antibiotics (Basel) Date: 2022-04-08
Authors: Peter Lackner; Ronny Beer; Gregor Broessner; Raimund Helbok; Klaus Galiano; Claudia Pleifer; Bettina Pfausler; Christian Brenneis; Christian Huck; Klaus Engelhardt; Alois A Obwegeser; Erich Schmutzhard Journal: Neurocrit Care Date: 2008 Impact factor: 3.210