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Literature DB >> 17764591

Antagonizing Methuselah to extend life span.

Abstract

A recent report describes the identification through the use of in vitro selection of a peptide that antagonizes Methuselah signaling in Drosophila in vitro and extends fly life span in vivo.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17764591 PMCID： PMC2374980 DOI： 10.1186/gb-2007-8-8-222

Source DB: PubMed Journal: Genome Biol ISSN： 1474-7596 Impact factor: 13.583

18 in total

1. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.

Authors: M Tatar; A Kopelman; D Epstein; M P Tu; C M Yin; R S Garofalo
Journal: Science Date: 2001-04-06 Impact factor: 47.728

Review 2. Orphan G-protein-coupled receptors and natural ligand discovery.

Authors: A D Howard; G McAllister; S D Feighner; Q Liu; R P Nargund; L H Van der Ploeg; A A Patchett
Journal: Trends Pharmacol Sci Date: 2001-03 Impact factor: 14.819

Review 3. Target validation of G-protein coupled receptors.

Authors: Alan Wise; Katy Gearing; Stephen Rees
Journal: Drug Discov Today Date: 2002-02-15 Impact factor: 7.851

4. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.

Authors: D J Clancy; D Gems; L G Harshman; S Oldham; H Stocker; E Hafen; S J Leevers; L Partridge
Journal: Science Date: 2001-04-06 Impact factor: 47.728

5. The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila.

Authors: Svetlana Cvejic; Zheng Zhu; Sarah J Felice; Yemiliya Berman; Xin-Yun Huang
Journal: Nat Cell Biol Date: 2004-05-09 Impact factor: 28.824

6. Dissociation between functional senescence and oxidative stress resistance in Drosophila.

Authors: Eric Cook-Wiens; Michael S Grotewiel
Journal: Exp Gerontol Date: 2002-12 Impact factor: 4.032

7. JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila.

Authors: Meng C Wang; Dirk Bohmann; Heinrich Jasper
Journal: Dev Cell Date: 2003-11 Impact factor: 12.270

8. Age-dependent stability of sensorimotor functions in the life-extended Drosophila mutant methuselah.

Authors: Agavni Petrosyan; I-Hui Hsieh; Kourosh Saberi
Journal: Behav Genet Date: 2007-05-30 Impact factor: 2.805

9. Presynaptic regulation of neurotransmission in Drosophila by the g protein-coupled receptor methuselah.

Authors: Wei Song; Ravi Ranjan; Ken Dawson-Scully; Peter Bronk; Leo Marin; Laurent Seroude; Yi-Jyun Lin; Zhiping Nie; Harold L Atwood; Seymour Benzer; Konrad E Zinsmaier
Journal: Neuron Date: 2002-09-26 Impact factor: 17.173

Review 10. Family-B G-protein-coupled receptors.

Authors: A J Harmar
Journal: Genome Biol Date: 2001-11-23 Impact factor: 13.583

3 in total

1. Bacterial Methionine Metabolism Genes Influence Drosophila melanogaster Starvation Resistance.

Authors: Alec M Judd; Melinda K Matthews; Rachel Hughes; Madeline Veloz; Corinne E Sexton; John M Chaston
Journal: Appl Environ Microbiol Date: 2018-08-17 Impact factor: 4.792

2. The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism Schmidtea mediterranea.

Authors: Mostafa Zamanian; Michael J Kimber; Paul McVeigh; Steve A Carlson; Aaron G Maule; Tim A Day
Journal: BMC Genomics Date: 2011-12-06 Impact factor: 3.969

3. Parasitization by Cotesia chilonis influences gene expression in fatbody and hemocytes of Chilo suppressalis.

Authors: Shun-Fan Wu; Fang-Da Sun; Yi-Xiang Qi; Yao Yao; Qi Fang; Jia Huang; David Stanley; Gong-Yin Ye
Journal: PLoS One Date: 2013-09-23 Impact factor: 3.240

3 in total