Literature DB >> 17764068

Bioactive ent-clerodane diterpenoids from Scutellaria barbata.

Sheng-Jun Dai1, Jing-Yong Sun, Yan Ren, Ke Liu, Li Shen.   

Abstract

Four new ENT-clerodane diterpenoids were isolated from the whole plant of Scutellaria barbata D. Don. (Labiatae). Their structures were elucidated by chemical methods and spectral analyses. in vitro, the four new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range 3.1-7.2 microM.

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Year:  2007        PMID： 17764068     DOI： 10.1055/s-2007-990215

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  7 in total

Review 1.  Clerodane diterpenes: sources, structures, and biological activities.

Authors:  Rongtao Li; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2016-07-18       Impact factor: 13.423

2.  Scutellaria barbate extract induces apoptosis of hepatoma H22 cells via the mitochondrial pathway involving caspase-3.

Authors:  Zhi-Jun Dai; Xi-Jing Wang; Zong-Fang Li; Zong-Zheng Ji; Hong-Tao Ren; Wei Tang; Xiao-Xu Liu; Hua-Feng Kang; Hai-Tao Guan; Ling-Qin Song
Journal:  World J Gastroenterol       Date:  2008-12-28       Impact factor: 5.742

3.  Chinese medicine formula "Shenqi San" extract inhibits proliferation of human lung adenocarcinoma A549 cells via inducing apoptosis.

Authors:  Yu Xia; Lu Shi; Zhong-Zhu Ai; De-Zhong Zhang; Yan-Wen Liu; Peng-Tao You
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2017-10-20

4.  In vitro and in vivo antitumor activity of Scutellaria barbate extract on murine liver cancer.

Authors:  Zhi-Jun Dai; Jie Gao; Zong-Fang Li; Zong-Zheng Ji; Hua-Feng Kang; Hai-Tao Guan; Yan Diao; Bao-Feng Wang; Xi-Jing Wang
Journal:  Molecules       Date:  2011-05-27       Impact factor: 4.411

5.  Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells.

Authors:  Idowu E Fadayomi; Okiemute R Johnson-Ajinwo; Elisabete Pires; James McCullagh; Tim D W Claridge; Nicholas R Forsyth; Wen-Wu Li
Journal:  Molecules       Date:  2021-09-30       Impact factor: 4.411

6.  Anti-angiogenic effect of the total flavonoids in Scutellaria barbata D. Don.

Authors:  Zhi-Jun Dai; Wang-Feng Lu; Jie Gao; Hua-Feng Kang; Yu-Guang Ma; Shu-Qun Zhang; Yan Diao; Shuai Lin; Xi-Jing Wang; Wen-Ying Wu
Journal:  BMC Complement Altern Med       Date:  2013-07-01       Impact factor: 3.659

7.  Total flavonoids of Scutellaria barbata inhibit invasion of hepatocarcinoma via MMP/TIMP in vitro.

Authors:  Zhi-Jun Dai; Bao-Feng Wang; Wang-Feng Lu; Zhi-Dong Wang; Xiao-Bin Ma; Wei-Li Min; Hua-Feng Kang; Xi-Jing Wang; Wen-Ying Wu
Journal:  Molecules       Date:  2013-01-11       Impact factor: 4.411
  7 in total

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