Radiesse nodule of the lips from a distant injection site: report of a case and consideration of etiology and management.

Radiesse was approved for cosmetic use by the US FDA in December of 2006. Prior to this approval it had been widely used off-label for a variety of areas including lip augmentation. With increased use, complications including nodule formation were reported. The formation of nodules at a site distant from the area of injection has not been reported to date. This report documents such a case and discusses possible etiologies and treatments for these distant nodules.