OBJECTIVE: Dysembryoplastic neuroepithelial tumors (DNTs) are clinicopathologically unique tumors. They are usually located within the supratentorial cortex, most often in the temporal lobe. These lesions are frequently associated with intractable complex partial seizures in children and young adults. DNTs may also arise outside of the cerebral cortex. We report a case of a 57-year-old woman who had a DNT in the caudate nucleus. During a 7-year follow-up period, the tumor did not recur. The literature on DNTs with atypical "ectopic" localizations is summarized. CLINICAL PRESENTATION: A patient presented with a 1-year history of headaches, nausea and vomiting, and progressive visual disturbances. INTERVENTION: Gross subtotal removal of the lesion was accomplished without further treatment. CONCLUSION: Unlike diffuse gliomas, such as oligodendrogliomas and central neurocytomas, DNTs are benign lesions with a favorable prognosis after surgical resection. Therefore, recognition of DNTs at atypical ectopic locations is essential for predicting the clinical course and for making the right therapeutic decisions.
OBJECTIVE:Dysembryoplastic neuroepithelial tumors (DNTs) are clinicopathologically unique tumors. They are usually located within the supratentorial cortex, most often in the temporal lobe. These lesions are frequently associated with intractable complex partial seizures in children and young adults. DNTs may also arise outside of the cerebral cortex. We report a case of a 57-year-old woman who had a DNT in the caudate nucleus. During a 7-year follow-up period, the tumor did not recur. The literature on DNTs with atypical "ectopic" localizations is summarized. CLINICAL PRESENTATION: A patient presented with a 1-year history of headaches, nausea and vomiting, and progressive visual disturbances. INTERVENTION: Gross subtotal removal of the lesion was accomplished without further treatment. CONCLUSION: Unlike diffuse gliomas, such as oligodendrogliomas and central neurocytomas, DNTs are benign lesions with a favorable prognosis after surgical resection. Therefore, recognition of DNTs at atypical ectopic locations is essential for predicting the clinical course and for making the right therapeutic decisions.
Authors: Calixto-Hope G Lucas; Javier E Villanueva-Meyer; Nicholas Whipple; Nancy Ann Oberheim Bush; Tabitha Cooney; Susan Chang; Michael McDermott; Mitchel Berger; Elaine Cham; Peter P Sun; Angelica Putnam; Hong Zhou; Robert Bollo; Samuel Cheshier; Matthew M Poppe; Kar-Ming Fung; Sarah Sung; Chad Glenn; Xuemo Fan; Serguei Bannykh; Jethro Hu; Moise Danielpour; Rong Li; Elizabeth Alva; James Johnston; Jessica Van Ziffle; Courtney Onodera; Patrick Devine; James P Grenert; Julieann C Lee; Melike Pekmezci; Tarik Tihan; Andrew W Bollen; Arie Perry; David A Solomon Journal: Brain Pathol Date: 2019-11-06 Impact factor: 6.508
Authors: Jason C H Chiang; Julie H Harreld; Ryuma Tanaka; Xiaoyu Li; Ji Wen; Chenran Zhang; Daniel R Boué; Tracy M Rauch; J Todd Boyd; Jie Chen; Joseph C Corbo; Thomas W Bouldin; Scott W Elton; Le-Wen L Liu; Deborah Schofield; Sunhee C Lee; John-Paul Bouffard; Maria-Magdalena Georgescu; Rimal H Dossani; Maria A Aguiar; Richard A Sances; Ali G Saad; Frederick A Boop; Ibrahim Qaddoumi; David W Ellison Journal: Neuro Oncol Date: 2019-06-10 Impact factor: 12.300