Shiro Ikegawa1. 1. Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, Tokyo, Japan. sikegawa@ims.u-tokyo.ac.jp
Abstract
PURPOSE OF REVIEW: Osteoarthritis is a serious medical, social and economic problem affecting populations worldwide. Identifying susceptibility genes for osteoarthritis is a critical step in tackling this disease. The association study is today's most powerful tool for finding such genes, and the osteoarthritis research community has enjoyed initial success through the identification of several promising candidates. This review summarizes recent advances and emerging challenges in osteoarthritis association studies. RECENT FINDINGS: Replication studies have confirmed association of functional sequence variations in the secreted frizzled-related protein 3 (FRZB) and asporin (ASPN) genes with osteoarthritis. These studies have also prompted discussion of population-specific differences in reported associations. Association of several other promising genes with osteoarthritis, including LRCH1, RHOB, TXNDC3 and GDF5, await replication. The Human Genome Project and the International HapMap Project have established an infrastructure to support genome-wide association studies. Large-scale case-control association scans are underway, and genome-wide association scans are also beginning. SUMMARY: Due to initial success in confirming several susceptibility genes and the advent of the post-genome sequence era, this area of osteoarthritis study is expanding quickly. To overcome current challenges and to move on to the next stage, however, international collaboration based on a common platform is essential.
PURPOSE OF REVIEW: Osteoarthritis is a serious medical, social and economic problem affecting populations worldwide. Identifying susceptibility genes for osteoarthritis is a critical step in tackling this disease. The association study is today's most powerful tool for finding such genes, and the osteoarthritis research community has enjoyed initial success through the identification of several promising candidates. This review summarizes recent advances and emerging challenges in osteoarthritis association studies. RECENT FINDINGS: Replication studies have confirmed association of functional sequence variations in the secreted frizzled-related protein 3 (FRZB) and asporin (ASPN) genes with osteoarthritis. These studies have also prompted discussion of population-specific differences in reported associations. Association of several other promising genes with osteoarthritis, including LRCH1, RHOB, TXNDC3 and GDF5, await replication. The Human Genome Project and the International HapMap Project have established an infrastructure to support genome-wide association studies. Large-scale case-control association scans are underway, and genome-wide association scans are also beginning. SUMMARY: Due to initial success in confirming several susceptibility genes and the advent of the post-genome sequence era, this area of osteoarthritis study is expanding quickly. To overcome current challenges and to move on to the next stage, however, international collaboration based on a common platform is essential.
Authors: Hsiang-Cheng Chen; Virginia Byers Kraus; Yi-Ju Li; Sarah Nelson; Carol Haynes; Jessica Johnson; Thomas Stabler; Elizabeth R Hauser; Simon G Gregory; William E Kraus; Svati H Shah Journal: Arthritis Rheum Date: 2010-03
Authors: Ana M Valdes; John Loughlin; Kirsten M Timms; Joyce J B van Meurs; Lorraine Southam; Scott G Wilson; Sally Doherty; Rik J Lories; Frank P Luyten; Alexander Gutin; Victor Abkevich; Dongliang Ge; Albert Hofman; André G Uitterlinden; Deborah J Hart; Feng Zhang; Guangju Zhai; Rainer J Egli; Michael Doherty; Jerry Lanchbury; Tim D Spector Journal: Am J Hum Genet Date: 2008-05-08 Impact factor: 11.025