Literature DB >> 1776238

Comparison of the metabolism of four sulphonamides between humans and pigs.

T B Vree1, E W Beneken Kolmer, A Peeters.   

Abstract

Pigs are unable to form N1-glucuronides of sulphadimethoxine and sulphamethomidine, while humans are able to do so. Pigs and humans are able to oxidise sulphapyridine and form the O-glucuronide. The double conjugate N4-acetylsulphapyridine-O-glucuronide is formed in humans but not in pigs. Sulphadiazine is mainly acetylated in both humans and pigs. A hypothesis about N1-glucuronidation is presented.

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Year:  1991        PMID： 1776238     DOI： 10.1080/01652176.1991.9694314

Source DB:  PubMed          Journal:  Vet Q        ISSN： 0165-2176            Impact factor:   3.320


  2 in total

1.  Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach.

Authors:  Floriane Lignet; Eva Sherbetjian; Nicole Kratochwil; Russell Jones; Claudia Suenderhauf; Michael B Otteneder; Thomas Singer; Neil Parrott
Journal:  Pharm Res       Date:  2016-07-28       Impact factor: 4.200

2.  Comparative Pharmacokinetics of Sulfadiazine and Its Metabolite N4-Acetyl Sulfadiazine in Grass Carp (Ctenopharyngodon idella) at Different Temperatures after Oral Administration.

Authors:  Ning Xu; Miao Li; Zhoumeng Lin; Xiaohui Ai
Journal:  Pharmaceutics       Date:  2022-03-26       Impact factor: 6.525
  2 in total

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