Rafael M Moreira1, Eduardo J Feres-Filho. 1. Graduate Periodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Abstract
BACKGROUND: The aim of this study was to test the hypothesis that there are no differences in clinical parameters in generalized aggressive periodontitis patients after full-mouth scaling androot planing (FRP) or quadrant-wise basic periodontal therapy (BPT) when combined with an antibiotic regimen. METHODS: Patients were allocated randomly to BPT (N = 15; mean age: 29.5 +/- 5.7 years) or FRP (N = 15; mean age: 28.4 +/- 5.7 years). All subjects received oral hygiene instructions including the use of a 0.12% chlorhexidine mouthrinse solution twice a day for 2 months. Patients also received amoxicillin, 500 mg, and metronidazole, 250 mg, three times a day for 7 days. Probing depth (PD), clinical attachment level, visible plaque, and bleeding on probing were recorded at baseline and at 2, 4, and 6 months post-therapy. Statistically significant changes within and between groups were determined using the general linear model repeated measures procedure. RESULTS: Both groups showed a significant improvement in all clinical parameters post-therapy, which was particularly evident at 2 months in the sites that had been deepest at baseline. For instance, the mean PD at sites with mean PD > or =7 mm at baseline had decreased 3.9 mm in the BPT group and 3.6 mm in the FRP group. At 6 months, the percentage of sites with PD > or =7 mm decreased from 13.2% +/- 3.2% to 0% in the BPT group and from 13.3% +/- 3.5% to 0.2% +/- 0.1% in the FRP group. No statistically significant differences were observed between groups for most clinical parameters. CONCLUSION: Within the limits of the present investigation, FRP and BPT caused comparable clinical effects in aggressive periodontitis patients when an adjunctive combined antibiotic regimen was included.
RCT Entities:
BACKGROUND: The aim of this study was to test the hypothesis that there are no differences in clinical parameters in generalized aggressive periodontitispatients after full-mouth scaling and root planing (FRP) or quadrant-wise basic periodontal therapy (BPT) when combined with an antibiotic regimen. METHODS:Patients were allocated randomly to BPT (N = 15; mean age: 29.5 +/- 5.7 years) or FRP (N = 15; mean age: 28.4 +/- 5.7 years). All subjects received oral hygiene instructions including the use of a 0.12% chlorhexidine mouthrinse solution twice a day for 2 months. Patients also received amoxicillin, 500 mg, and metronidazole, 250 mg, three times a day for 7 days. Probing depth (PD), clinical attachment level, visible plaque, and bleeding on probing were recorded at baseline and at 2, 4, and 6 months post-therapy. Statistically significant changes within and between groups were determined using the general linear model repeated measures procedure. RESULTS: Both groups showed a significant improvement in all clinical parameters post-therapy, which was particularly evident at 2 months in the sites that had been deepest at baseline. For instance, the mean PD at sites with mean PD > or =7 mm at baseline had decreased 3.9 mm in the BPT group and 3.6 mm in the FRP group. At 6 months, the percentage of sites with PD > or =7 mm decreased from 13.2% +/- 3.2% to 0% in the BPT group and from 13.3% +/- 3.5% to 0.2% +/- 0.1% in the FRP group. No statistically significant differences were observed between groups for most clinical parameters. CONCLUSION: Within the limits of the present investigation, FRP and BPT caused comparable clinical effects in aggressive periodontitispatients when an adjunctive combined antibiotic regimen was included.
Authors: Sherin N Merchant; Andrea Vovk; Danny Kalash; Nicole Hovencamp; Ikramuddin Aukhil; Peter Harrison; Edward Zapert; John Bidwell; Phyllis Varnado; Luciana M Shaddox Journal: J Periodontol Date: 2014-12 Impact factor: 6.993
Authors: Karina A F S Miller; Luciana S Branco-de-Almeida; Sandra Wolf; Nicole Hovencamp; Tina Treloar; Peter Harrison; Ikramuddin Aukhil; Yan Gong; Luciana M Shaddox Journal: J Clin Periodontol Date: 2016-12-27 Impact factor: 8.728