Literature DB >> 1775161

Primary structure of a Plasmodium falciparum rhoptry antigen.

H J Brown1, R L Coppel.   

Abstract

The high-molecular-weight rhoptry complex of Plasmodium falciparum consists of 3 non-covalently associated polypeptides of 150, 135 and 105 kDa. We present the complete nucleotide sequence of the 105-kDa (RhopH3) component of this complex derived from analysis of genomic and cDNA clones. The genomic structure is unusually complex for P. falciparum, consisting of 7 exons including 2 mini-exons of 19 and 21 amino acids. The sequence lacks tandem repeats and is conserved among several parasite isolates. B cell epitopes that induce antibody responses during natural infection were mapped to five different regions of the polypeptide.

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Year:  1991        PMID： 1775161     DOI： 10.1016/0166-6851(91)90133-q

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  15 in total

1.  Structural and antigenic properties of merozoite surface protein 4 of Plasmodium falciparum.

Authors:  L Wang; C G Black; V M Marshall; R L Coppel
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

2.  In vitro biosynthesis and in vivo processing of the major microneme antigen of Sarcocystis muris cyst merozoites.

Authors:  H Klein; H Mehlhorn; W Rüger
Journal:  Parasitol Res       Date:  1996       Impact factor: 2.289

3.  Assessment of the humoral immune response against Plasmodium falciparum rhoptry-associated proteins 1 and 2.

Authors:  A Stowers; D Taylor; N Prescott; Q Cheng; J Cooper; A Saul
Journal:  Infect Immun       Date:  1997-06       Impact factor: 3.441

Review 4.  Cell invasion by the vertebrate stages of Plasmodium.

Authors:  P Sinnis; B K Sim
Journal:  Trends Microbiol       Date:  1997-02       Impact factor: 17.079

5.  Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum.

Authors:  P H Jakobsen; L Hviid; T G Theander; E A Afare; R G Ridley; P M Heegaard; D Stuber; K Dalsgaard; F K Nkrumah
Journal:  Infect Immun       Date:  1993-01       Impact factor: 3.441

6.  Identification and characterization of the Plasmodium falciparum RhopH2 ortholog in Plasmodium vivax.

Authors:  Bo Wang; Feng Lu; Yang Cheng; Jian Li; Daisuke Ito; Jetsumon Sattabongkot; Takafumi Tsuboi; Eun-Taek Han
Journal:  Parasitol Res       Date:  2012-10-25       Impact factor: 2.289

7.  Diversity and evolution of the rhoph1/clag multigene family of Plasmodium falciparum.

Authors:  Hideyuki Iriko; Osamu Kaneko; Hitoshi Otsuki; Takafumi Tsuboi; Xin-Zhuan Su; Kazuyuki Tanabe; Motomi Torii
Journal:  Mol Biochem Parasitol       Date:  2007-11-17       Impact factor: 1.759

8.  Rhop-3 protein conservation among Plasmodium species and induced protection against lethal P. yoelii and P. berghei challenge.

Authors:  Tongmin Wang; Hisashi Fujioka; Judith A Drazba; Tobili Y Sam-Yellowe
Journal:  Parasitol Res       Date:  2006-03-16       Impact factor: 2.289

9.  Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum.

Authors:  T Triglia; A F Cowman
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-19       Impact factor: 11.205

10.  Identification of Plasmodium falciparum RhopH3 protein peptides that specifically bind to erythrocytes and inhibit merozoite invasion.

Authors:  Carlos Giovanni Pinzón; Hernando Curtidor; Claudia Reyes; David Méndez; Manuel Elkin Patarroyo
Journal:  Protein Sci       Date:  2008-07-01       Impact factor: 6.725
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