Literature DB >> 1774399

Sedation by propofol in tetanus--is it a muscular relaxant?

A Borgeat1, C Dessibourg, M Rochani, P M Suter.   

Abstract

We investigated the muscular relaxant properties of propofol in a 54 year-old-man with severe tetanus. Four consecutive boluses of propofol 50 mg i.v. were administered. Mean muscular activity recorded on an electromyography (EMG) decreased from 100 to 10-25 mV within 15 s after each bolus. EMG values were restored to prior levels 10 min after the last bolus. Maximum decrease of muscular activity was observed with propofol blood level between 2.90-3.20 micrograms.ml-1. Neuromuscular function recorded by means of evoked electromyography was not affected by propofol administration.

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Year:  1991        PMID： 1774399     DOI： 10.1007/bf01720683

Source DB:  PubMed          Journal:  Intensive Care Med        ISSN： 0342-4642            Impact factor:   17.440


  8 in total

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Authors:  P S Sebel; J D Lowdon
Journal:  Anesthesiology       Date:  1989-08       Impact factor: 7.892

2.  Efficiency of a continuous infusion of propofol in a patient with tetanus.

Authors:  A Borgeat; V Popovic; D Schwander
Journal:  Crit Care Med       Date:  1991-02       Impact factor: 7.598

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Journal:  Clin Neuropharmacol       Date:  1986       Impact factor: 1.592

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5.  Lack of effects of emulsified propofol ('Diprivan') on vecuronium pharmacodynamics--preliminary results in man.

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Journal:  Postgrad Med J       Date:  1985       Impact factor: 2.401

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Authors:  D D Alfery; L A Rauscher
Journal:  Crit Care Med       Date:  1979-04       Impact factor: 7.598

7.  Tetanus and its complications: intensive care and management experience in 150 Indian patients.

Authors:  F E Udwadia; A Lall; Z F Udwadia; M Sekhar; A Vora
Journal:  Epidemiol Infect       Date:  1987-12       Impact factor: 2.451

8.  Propofol infusion for sedation in intensive care.

Authors:  L H Newman; J C McDonald; P G Wallace; I M Ledingham
Journal:  Anaesthesia       Date:  1987-09       Impact factor: 6.955
  8 in total
  7 in total

Review 1.  Tetanus.

Authors:  J J Farrar; L M Yen; T Cook; N Fairweather; N Binh; J Parry; C M Parry
Journal:  J Neurol Neurosurg Psychiatry       Date:  2000-09       Impact factor: 10.154

Review 2.  Post-neonatal tetanus: issues in intensive care management.

Authors:  S Singhi; V Jain; C Subramanian
Journal:  Indian J Pediatr       Date:  2001-03       Impact factor: 1.967

Review 3.  [Treatment strategies for tetanus].

Authors:  T Duning; W R Schäbitz
Journal:  Nervenarzt       Date:  2007-02       Impact factor: 1.214

Review 4.  Propofol: a review of its use in intensive care sedation of adults.

Authors:  Kate McKeage; Caroline M Perry
Journal:  CNS Drugs       Date:  2003       Impact factor: 5.749

5.  Tetanus.

Authors:  Sarice L. Bassin
Journal:  Curr Treat Options Neurol       Date:  2004-01       Impact factor: 3.598

Review 6.  Propofol. An update of its use in anaesthesia and conscious sedation.

Authors:  H M Bryson; B R Fulton; D Faulds
Journal:  Drugs       Date:  1995-09       Impact factor: 9.546

Review 7.  Propofol. An overview of its pharmacology and a review of its clinical efficacy in intensive care sedation.

Authors:  B Fulton; E M Sorkin
Journal:  Drugs       Date:  1995-10       Impact factor: 9.546
  7 in total

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