Literature DB >> 177326

Re-evaluation of the role of cyclic AMP in histamine-induced gastric acid secretion.

G C Rosenfeld, E D Jacobson, W J Thompson.   

Abstract

The 600 x g particulate fraction of gastric mucosal scrapings from rats was incubated with 3H-metiamide which saturated available binding sites at a concentration of 1 muM. Scatchard plots showed a single component with a Kd value of 0.2 muM. Unlabelled cimetidine and histamine competed with 3H-metiamide binding. The 600 x g particulate fraction also contained all of the hormone and sodium fluoride sensitive adenylyl cyclase. Adenylyl cyclase activity was not altered by histamine, pentagastrin or carbachol but was increased during incubation with prostaglandin E1, secretin and epinephrine. These findings do not support the hypthesis that gastric secretion is mediated by intracellular accumulation of cyclic AMP.

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Year:  1976        PMID： 177326

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  7 in total

1.  Indomethacin-induced intestinal inflammation.

Authors:  W F Fang; A Broughton; E D Jacobson
Journal:  Am J Dig Dis       Date:  1977-09

2.  The localization of a histamine H2-receptor adenylate cyclase system in canine parietal cells and its inhibition by prostaglandins.

Authors:  J S Major; P Scholes
Journal:  Agents Actions       Date:  1978-06

Review 3.  Recent advances in the treatment of duodenal ulcer disease. A surgical perspective.

Authors:  M W Mulholland; H T Debas
Journal:  West J Med       Date:  1987-09

4.  The binding of [3H]-tiotidine to homogenates of guinea-pig lung parenchyma.

Authors:  J C Foreman; D B Norris; T J Rising; S E Webber
Journal:  Br J Pharmacol       Date:  1985-10       Impact factor: 8.739

5.  Relation between pharmacological response and receptor binding with histamine blocking drugs. Irreversible antagonism of three analogues of mifentidine on right atrium and cerebral cortex of the guinea-pig.

Authors:  K Kramer; A Bast; H Timmerman
Journal:  Agents Actions       Date:  1987-06

6.  An experimental study on histamine H2-receptor antagonist on calcium, gastrin and histamine induced gastric acid secretion in rat.

Authors:  K Segawa; S Nakazawa; Y Naito; K Imai; T Kachi; S Tsukamoto; M Kajikawa; M Aichi; E Kimoto; H Sano; J Tominaga; T Ichikawa; T Oida; T Yoshino
Journal:  Gastroenterol Jpn       Date:  1979-12

7.  Binding of [3H]ICIA 5165, an H2-receptor antagonist to guinea pig gastric mucosa.

Authors:  S T Nielsen
Journal:  Agents Actions       Date:  1986-08
  7 in total

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