OBJECTIVE: To study the evolution of lipid peroxidation, enzymatic antioxidants response, lipid profile and membrane fluidity in erythrocytes from very low birth weight (VLBW) infants during their first 7 days of extra-uterine life. STUDY DESIGN: One hundred and twenty infants were selected and divided in two groups according to their weight and gestational age. Hydroperoxides, fatty-acid profile, fluidity (DPH and TMA-DPH) and catalase, SOD and GPx activities were measured in erythrocytes. RESULTS: VLBW group showed higher concentration of hydroperoxides and lower membrane fluidity during the first 72 h, lower SOD activity during the first 3 h and higher GPx activity during the first 7 days of life. Also, this group showed lower n-3 polyunsaturated fatty-acids percentage with respect to the term group. CONCLUSION: Erythrocytes from VLBW infants showed higher oxidative damage and lower fluidity in their membranes, at least during the first 3 days of extra-uterine life, which may cause alterations in their functions and flexibility.
OBJECTIVE: To study the evolution of lipid peroxidation, enzymatic antioxidants response, lipid profile and membrane fluidity in erythrocytes from very low birth weight (VLBW) infants during their first 7 days of extra-uterine life. STUDY DESIGN: One hundred and twenty infants were selected and divided in two groups according to their weight and gestational age. Hydroperoxides, fatty-acid profile, fluidity (DPH and TMA-DPH) and catalase, SOD and GPx activities were measured in erythrocytes. RESULTS: VLBW group showed higher concentration of hydroperoxides and lower membrane fluidity during the first 72 h, lower SOD activity during the first 3 h and higher GPx activity during the first 7 days of life. Also, this group showed lower n-3 polyunsaturated fatty-acids percentage with respect to the term group. CONCLUSION: Erythrocytes from VLBW infants showed higher oxidative damage and lower fluidity in their membranes, at least during the first 3 days of extra-uterine life, which may cause alterations in their functions and flexibility.
Authors: Javier Diaz-Castro; Mario Pulido-Moran; Jorge Moreno-Fernandez; Naroa Kajarabille; Catalina de Paco; Maria Garrido-Sanchez; Sonia Prados; Julio J Ochoa Journal: Pediatr Res Date: 2016-05-24 Impact factor: 3.756
Authors: Javier Díaz-Castro; Jesus Florido; Naroa Kajarabille; Sonia Prados; Catalina de Paco; Olga Ocon; Mario Pulido-Moran; Julio J Ochoa Journal: Oxid Med Cell Longev Date: 2015-02-01 Impact factor: 6.543
Authors: Asmaa N Moustafa; Mahmoud H Ibrahim; Suzan Omar Mousa; Ebtesam E Hassan; Hashem F Mohamed; Hend M Moness Journal: Lipids Health Dis Date: 2017-11-09 Impact factor: 3.876