Literature DB >> 17727986

Inflammation, endothelial dysfunction and angiogenesis markers in chronic heart failure patients.

Virtudes Vila, Vicenta Martínez-Sales, Luis Almenar, Ignacio Sánchez Lázaro, Piedad Villa, Edelmiro Reganon.   

Abstract

This study was conducted to assess the relationship among circulating markers of inflammation, endothelial dysfunction and angiogenesis in 59 chronic heart failure (CHF) patients. Increased concentrations of C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-alpha), von Willebrand factor (VWF) and fibrinogen are strongly implicated in the development of CHF. Increased vascular endothelium grow factor (VEGF) and decreased thrombospondin-1 (TSP-1) concentrations suggest a role of angiogenesis in the maintenance and repair of luminal endothelium in CHF. A relationship among markers of endothelial dysfunction (VWF) and inflammation (fibrinogen, CRP) and angiogenesis (VEGF, TSP-1) was found in CHF patients.

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Year:  2007        PMID： 17727986     DOI： 10.1016/j.ijcard.2007.07.010

Source DB:  PubMed          Journal:  Int J Cardiol        ISSN： 0167-5273            Impact factor:   4.164


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