[Hemostatic disturbances in obesity].

Overweight and obesity belong to the group of chronic diseases in which there is a substantially increased risk of thromboembolic incidents. The changes involve both arterial and venous system. The decisive role in their development seems to have disorders ofhemostasis including both excessive activation of coagulation system and/or inhibition of fibrinolysis. Coagulation changes in obese persons are complex. They include, among others, increase in concentration and activity of blood clotting factors, hyperfibrynogenemia and overeactivity ofplatelets. On the other hand, inhibition of normal fibrinolysis occurs in obese persons. The goal of this study was to examine disorders of coagulation and fibrinolysis developing in obese persons, taking also into account hormonal and metabolic changes, endothelium damage and the influence of adipocytokines on the hemostasis mechanisms.