OBJECTIVE: Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. We evaluated candidate functional polymorphism of the G protein beta3 subunit (GNB3) gene for association with drug-induced TD in the Korean schizophrenic patients. METHODS: We investigated whether the C825T polymorphism of the GNB3 gene is associated with the TD in a Korean sample of schizophrenic patients with (n = 83) and without TD (n = 126), matched for antipsychotic drug exposure and other relevant variables. RESULTS: The distribution of genotypes and allele frequencies of GNB3 were not different between schizophrenic patients with TD and without TD (p > 0.05). CONCLUSION: Within the limitations imposed by the size of the clinical sample, these findings suggest that the GNB3 825 C/T single nucleotide polymorphism (SNP) does not contribute significantly to risk for TD.
OBJECTIVE:Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. We evaluated candidate functional polymorphism of the G protein beta3 subunit (GNB3) gene for association with drug-induced TD in the Korean schizophrenicpatients. METHODS: We investigated whether the C825T polymorphism of the GNB3 gene is associated with the TD in a Korean sample of schizophrenicpatients with (n = 83) and without TD (n = 126), matched for antipsychotic drug exposure and other relevant variables. RESULTS: The distribution of genotypes and allele frequencies of GNB3 were not different between schizophrenicpatients with TD and without TD (p > 0.05). CONCLUSION: Within the limitations imposed by the size of the clinical sample, these findings suggest that the GNB3825 C/T single nucleotide polymorphism (SNP) does not contribute significantly to risk for TD.