Literature DB >> 17726379

Beta2-chimaerin in cancer signaling: connecting cell adhesion and MAP kinase activation.

Stephen P Bruinsma1, Thomas J Baranski.   

Abstract

The chimaerins are Rac GTPase-activating proteins that bind diacylglycerol. Emerging evidence implicates beta2-chimaerin in tumor progression. Here, we discuss our recent work in Drosophila melanogaster in the context of previous studies performed in human cancer cell lines that together lend new mechanistic insight into the role of chimaerins in cancer.

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Year:  2007        PMID： 17726379     DOI： 10.4161/cc.6.20.4786

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  8 in total

1.  Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.

Authors:  Lia C Garcia; Lucia Gandolfi Donadío; Ella Mann; Sofiya Kolusheva; Noemi Kedei; Nancy E Lewin; Colin S Hill; Jessica S Kelsey; Jing Yang; Timothy E Esch; Marina Santos; Megan L Peach; James A Kelley; Peter M Blumberg; Raz Jelinek; Victor E Marquez; Maria J Comin
Journal:  Bioorg Med Chem       Date:  2014-04-20       Impact factor: 3.641

2.  Subgroup-specific alternative splicing in medulloblastoma.

Authors:  Adrian M Dubuc; A Sorana Morrissy; Nanne K Kloosterhof; Paul A Northcott; Emily Py Yu; David Shih; John Peacock; Wieslawa Grajkowska; Timothy van Meter; Charles G Eberhart; Stefan Pfister; Marco A Marra; William A Weiss; Stephen W Scherer; James T Rutka; Pim J French; Michael D Taylor
Journal:  Acta Neuropathol       Date:  2012-02-23       Impact factor: 17.088

3.  Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP.

Authors:  Eleonora Elhalem; Lucía Gandolfi Donadío; Xiaoling Zhou; Nancy E Lewin; Lia C Garcia; Christopher C Lai; James A Kelley; Megan L Peach; Peter M Blumberg; María J Comin
Journal:  Bioorg Med Chem       Date:  2017-03-10       Impact factor: 3.641

Review 4.  Wealth of opportunity - the C1 domain as a target for drug development.

Authors:  P M Blumberg; N Kedei; N E Lewin; D Yang; G Czifra; Y Pu; M L Peach; V E Marquez
Journal:  Curr Drug Targets       Date:  2008-08       Impact factor: 3.465

5.  CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients.

Authors:  Cheng Hu; Rong Zhang; Weihui Yu; Jie Wang; Congrong Wang; Can Pang; Xiaojing Ma; Yuqian Bao; Kunsan Xiang; Weiping Jia
Journal:  Diabetes       Date:  2011-09-12       Impact factor: 9.461

6.  Induction of endoplasmic reticulum calcium pump expression during early leukemic B cell differentiation.

Authors:  Lamia Aït Ghezali; Atousa Arbabian; Hervé Roudot; Jean-Philippe Brouland; Fanny Baran-Marszak; Evelyn Salvaris; Andrew Boyd; Hans G Drexler; Agnes Enyedi; Remi Letestu; Nadine Varin-Blank; Bela Papp
Journal:  J Exp Clin Cancer Res       Date:  2017-06-26

7.  Severe insulin resistance and intrauterine growth deficiency associated with haploinsufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism.

Authors:  Sara G I Suliman; Juraj Stanik; Laura J McCulloch; Natalie Wilson; Emma L Edghill; Nadezda Misovicova; Daniela Gasperikova; Vilja Sandrikova; Katherine S Elliott; Lubomir Barak; Sian Ellard; Emanuela V Volpi; Iwar Klimes; Anna L Gloyn
Journal:  Diabetes       Date:  2009-08-31       Impact factor: 9.461

8.  CHN1 promotes epithelial-mesenchymal transition via the Akt/GSK-3β/Snail pathway in cervical carcinoma.

Authors:  Haoqi Zhao; Lan Wang; Shufang Wang; Xihua Chen; Min Liang; Xin Zhang; Jiedong Wang; Xiangbo Xu
Journal:  J Transl Med       Date:  2021-07-08       Impact factor: 5.531
  8 in total

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