Literature DB >> 17724814

Hepatocellular carcinoma masquerading as a bleeding gastric ulcer: a case report and a review of the surgical management.

Johnny C A Ong1, Pierce K H Chow, Weng-Hoong Chan, Alex Y F Chung, Choon Hua Thng, Wai-Keong Wong.   

Abstract

Hepatocellular Carcinoma (HCC) is a common malignancy worldwide. While bleeding from the gastrointestinal tract (BGIT) has a well known association with HCC, such cases are mainly due to gastric and esophageal varices. BGIT as a result of invasion of the gastrointestinal tract by HCC is extremely rare and is reportedly associated with very poor prognosis. We describe a 67-year-old male who presented with BGIT. Endoscopy showed the site of bleeding to be from a gastric ulcer, but endoscopic therapy failed to control the bleeding and emergency surgery was required. At surgery, the ulcer was found to have arisen from direct invasion of the gastrointestinal tract by HCC of the left lobe. Control of the bleeding was achieved by surgical resection of the HCC en-bloc with the lesser curve of the stomach. The patient remains alive 33 mo after surgery. Direct invasion of the gastrointestinal tract by HCC giving rise to BGIT is very uncommon. Surgical resection may offer significantly better survival over non-surgical therapy, especially if the patient is a good surgical candidate and has adequate functional liver reserves. Prognosis is not uniformly grave.

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Year:  2007        PMID: 17724814      PMCID: PMC4611591          DOI: 10.3748/wjg.v13.i33.4523

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN: 1007-9327            Impact factor:   5.742


  13 in total

1.  Primary carcinoma of the liver: a study of 282 cases in Ugandan Africans.

Authors:  P P Anthony
Journal:  J Pathol       Date:  1973-05       Impact factor: 7.996

2.  Gastrointestinal bleeding from hepatocellular carcinoma invading the stomach.

Authors:  A J Nicoll; H J Ireton; B Crotty
Journal:  J Gastroenterol Hepatol       Date:  1994 Sep-Oct       Impact factor: 4.029

3.  Hepatocellular carcinoma complicated by gastrointestinal hemorrhage caused by direct tumor invasion of stomach.

Authors:  A Maruyama; K Murabayashi; M Hayashi; H Nakano; S Isaji; S Uehara; T Kusuda; S Miyahara; A Kondo; T Yabana
Journal:  J Hepatobiliary Pancreat Surg       Date:  1999

4.  Gastrointestinal metastasis in hepatocellular carcinoma: radiological and endoscopic studies of 11 cases.

Authors:  C P Lin; J S Cheng; K H Lai; G H Lo; P I Hsu; H H Chan; J H Hsu; Y Y Wang; H B Pan; H H Tseng
Journal:  J Gastroenterol Hepatol       Date:  2000-05       Impact factor: 4.029

5.  Gastrointestinal hemorrhage in hepatocellular carcinoma: management with transheptic arterioembolization.

Authors:  D N Srivastava; D Gandhi; P K Julka; R K Tandon
Journal:  Abdom Imaging       Date:  2000 Jul-Aug

6.  Gastrointestinal tract involvement in hepatocellular carcinoma: clinical, radiological and endoscopic studies.

Authors:  L T Chen; C Y Chen; C M Jan; W M Wang; T S Lan; M Y Hsieh; G C Liu
Journal:  Endoscopy       Date:  1990-05       Impact factor: 10.093

7.  Pathology of hepatocellular carcinoma in Japan. 232 Consecutive cases autopsied in ten years.

Authors:  T Nakashima; K Okuda; M Kojiro; A Jimi; R Yamaguchi; K Sakamoto; T Ikari
Journal:  Cancer       Date:  1983-03-01       Impact factor: 6.860

Review 8.  Hepatocellular carcinoma: update on diagnosis and treatment.

Authors:  W H Ramsey; G Y Wu
Journal:  Dig Dis       Date:  1995 Mar-Apr       Impact factor: 2.404

9.  A prospective study of upper gastrointestinal hemorrhage in patients with hepatocellular carcinoma.

Authors:  W Yeo; J Y Sung; S C Ward; S C Chung; W Y Lee; A K Li; P J Johnson
Journal:  Dig Dis Sci       Date:  1995-12       Impact factor: 3.199

10.  [Multidisciplinary treatment for hepatocellular carcinoma invading the stomach].

Authors:  Masafumi Takahashi; Toru Beppu; Koichi Doi; Takatoshi Ishiko; Kazuharu Kai; Yasuro Doi; Hirohisa Okabe; Hiroshi Egami; Hiroshi Ashihara; Shigetoshi Fujiyama; Michio Ogawa
Journal:  Gan To Kagaku Ryoho       Date:  2003-10
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  2 in total

Review 1.  Direct biliopancreatoduodenal invasion by hepatocellular carcinoma: report of the first resected case and review of the literature.

Authors:  Yutaro Kato; Kentaro Matsubara; Yoshinobu Akiyama; Hiroaki Hattori; Akira Hirata; Tatsuya Yamamoto; Fumio Suzuki; Hitoshi Ohtaka; Yoshiaki Sugiura; Masaki Kitajima
Journal:  Int J Clin Oncol       Date:  2010-10-21       Impact factor: 3.402

Review 2.  Hepatocellular Carcinoma with Gastrointestinal Involvement: A Systematic Review.

Authors:  Cristiana Marinela Urhut; Larisa Daniela Sandulescu; Liliana Streba; Vlad Florin Iovanescu; Sarmis Marian Sandulescu; Suzana Danoiu
Journal:  Diagnostics (Basel)       Date:  2022-05-19
  2 in total

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