L Raffi1, L Simonetti, P Cenni, M Leonardi. 1. Servizio di Neuroradiologia, Ospedale Bellaria, Via Altura 3, 40139 Bologna, Italy. luisa.raffi@ausl.bologna.it
Abstract
INTRODUCTION: Glubran 2 is a cyanoacrylate-based synthetic glue modified by the addition of a monomer synthesized by the manufacturer. With this material it is possible to obtain the stability of endovascular embolization that is needed to treat tumours and vascular disease. MATERIAL AND METHODS: We report our 3-year experience of the use of Glubran for treating extracerebral tumours, spinal tumours, spinal arteriovenous malformations, and brain and spine dural fistulae. Glubran 2 was diluted with Lipiodol and injected in a continuous column with the flow rate monitored by seriography. The injection was stopped when retrograde flow was displayed in the afferent vessel. RESULTS: There were no periprocedural or subsequent clinical complications and the glue resulted in successful selective permanent occlusion with intralesional penetration similar to the angiographic features of microcatheterization. CONCLUSIONS: The embolization procedure was technically straightforward and relatively safe. However, Glubran 2 can be difficult to use and the procedure does carry major risks for patients. Glue injection requires in-depth study of the lesion, its circulation and the collateral circulation to avoid severe complications due to inappropriate use.
INTRODUCTION:Glubran 2 is a cyanoacrylate-based synthetic glue modified by the addition of a monomer synthesized by the manufacturer. With this material it is possible to obtain the stability of endovascular embolization that is needed to treat tumours and vascular disease. MATERIAL AND METHODS: We report our 3-year experience of the use of Glubran for treating extracerebral tumours, spinal tumours, spinal arteriovenous malformations, and brain and spine dural fistulae. Glubran 2 was diluted with Lipiodol and injected in a continuous column with the flow rate monitored by seriography. The injection was stopped when retrograde flow was displayed in the afferent vessel. RESULTS: There were no periprocedural or subsequent clinical complications and the glue resulted in successful selective permanent occlusion with intralesional penetration similar to the angiographic features of microcatheterization. CONCLUSIONS: The embolization procedure was technically straightforward and relatively safe. However, Glubran 2 can be difficult to use and the procedure does carry major risks for patients. Glue injection requires in-depth study of the lesion, its circulation and the collateral circulation to avoid severe complications due to inappropriate use.
Authors: L Raffi; L Simonetti; P Cenni; S Bandiera; A Gasbarrini; S Boriani; M Leonardi Journal: Interv Neuroradiol Date: 2004-10-22 Impact factor: 1.610
Authors: M Leonardi; P Cenni; L Simonetti; A Bozzao; A Romano; M Bonamini; L M Fantozzi; G Fini Journal: Interv Neuroradiol Date: 2004-10-22 Impact factor: 1.610
Authors: M Leonardi; C Barbara; L Simonetti; R Giardino; N Nicoli Aldini; M Fini; L Martini; L Masetti; M Joechler; F Roncaroli Journal: Interv Neuroradiol Date: 2004-10-20 Impact factor: 1.610
Authors: H B Shi; D C Suh; H K Lee; S M Lim; D H Kim; C G Choi; C S Lee; S C Rhim Journal: AJNR Am J Neuroradiol Date: 1999 Nov-Dec Impact factor: 3.825
Authors: Giovanni Di Nardo; Valentino Valentini; Diletta Angeletti; Simone Frediani; Giannicola Iannella; Denis Cozzi; Mario Roggini; Giuseppe Magliulo Journal: SAGE Open Med Case Rep Date: 2016-10-13