PURPOSE: To determine the heritability of refractive error and familial aggregation of myopia and hyperopia in an elderly Old Order Amish (OOA) population. METHODS: Nine hundred sixty-seven siblings (mean age, 64.2 years) in 269 families were recruited for the Amish Eye Study in the Lancaster County area of Pennsylvania. Refractive error was determined by noncycloplegic manifest refraction. Heritability of refractive error was estimated with multivariate linear regression as twice the residual sibling-sibling correlation after adjustment for age and gender. Logistic regression models were used to estimate the sibling recurrence odds ratio (OR(s)). Myopia and hyperopia were defined with five different thresholds. RESULTS: The age- and gender-adjusted heritability of refractive error was 70% (95% CI: 48%-92%) in the OOA. Age and gender-adjusted OR(s) and sibling recurrence risk (lambda(s)), with different thresholds defining myopia ranged from 3.03 (95% CI: 1.58-5.80) to 7.02 (95% CI: 3.41-14.46) and from 2.36 (95% CI: 1.65-3.19) to 5.61 (95% CI: 3.06-9.34). Age and gender-adjusted OR(s) and lambda(s) for different thresholds of hyperopia ranged from 2.31 (95% CI: 1.56-3.42) to 2.94 (95% CI: 2.04-4.22) and from 1.33 (95% CI: 1.22-1.43) to 1.85 (95% CI: 1.18-2.78), respectively. Women were significantly more likely than men to have hyperopia. There was no significant gender difference in the risk of myopia. CONCLUSIONS: In the OOA, refractive error is highly heritable. Hyperopia and myopia aggregate strongly in OOA families.
PURPOSE: To determine the heritability of refractive error and familial aggregation of myopia and hyperopia in an elderly Old Order Amish (OOA) population. METHODS: Nine hundred sixty-seven siblings (mean age, 64.2 years) in 269 families were recruited for the Amish Eye Study in the Lancaster County area of Pennsylvania. Refractive error was determined by noncycloplegic manifest refraction. Heritability of refractive error was estimated with multivariate linear regression as twice the residual sibling-sibling correlation after adjustment for age and gender. Logistic regression models were used to estimate the sibling recurrence odds ratio (OR(s)). Myopia and hyperopia were defined with five different thresholds. RESULTS: The age- and gender-adjusted heritability of refractive error was 70% (95% CI: 48%-92%) in the OOA. Age and gender-adjusted OR(s) and sibling recurrence risk (lambda(s)), with different thresholds defining myopia ranged from 3.03 (95% CI: 1.58-5.80) to 7.02 (95% CI: 3.41-14.46) and from 2.36 (95% CI: 1.65-3.19) to 5.61 (95% CI: 3.06-9.34). Age and gender-adjusted OR(s) and lambda(s) for different thresholds of hyperopia ranged from 2.31 (95% CI: 1.56-3.42) to 2.94 (95% CI: 2.04-4.22) and from 1.33 (95% CI: 1.22-1.43) to 1.85 (95% CI: 1.18-2.78), respectively. Women were significantly more likely than men to have hyperopia. There was no significant gender difference in the risk of myopia. CONCLUSIONS: In the OOA, refractive error is highly heritable. Hyperopia and myopia aggregate strongly in OOA families.
Authors: L Naiglin; C Gazagne; F Dallongeville; C Thalamas; A Idder; O Rascol; F Malecaze; P Calvas Journal: J Med Genet Date: 2002-02 Impact factor: 6.318
Authors: Jeremy A Guggenheim; Ricardo Pong-Wong; Chris S Haley; Gus Gazzard; Seang Mei Saw Journal: Br J Ophthalmol Date: 2006-11-29 Impact factor: 4.638
Authors: Prasuna Paluru; Shawn M Ronan; Elise Heon; Marcella Devoto; Scott C Wildenberg; Genaro Scavello; Ann Holleschau; Outi Mäkitie; William G Cole; Richard A King; Terri L Young Journal: Invest Ophthalmol Vis Sci Date: 2003-05 Impact factor: 4.799
Authors: Dennis S C Lam; Pancy O S Tam; Dorothy S P Fan; Larry Baum; Yuk-fai Leung; Chi Pui Pang Journal: Ophthalmologica Date: 2003 Mar-Apr Impact factor: 3.250
Authors: David Troilo; Earl L Smith; Debora L Nickla; Regan Ashby; Andrei V Tkatchenko; Lisa A Ostrin; Timothy J Gawne; Machelle T Pardue; Jody A Summers; Chea-Su Kee; Falk Schroedl; Siegfried Wahl; Lyndon Jones Journal: Invest Ophthalmol Vis Sci Date: 2019-02-28 Impact factor: 4.799
Authors: Anthony M Musolf; Claire L Simpson; Theresa A Alexander; Laura Portas; Federico Murgia; Elise B Ciner; Dwight Stambolian; Joan E Bailey-Wilson Journal: Hum Genet Date: 2019-03-02 Impact factor: 4.132
Authors: Woei-Jyh Lee; Toni I Pollin; Jeffrey R O'Connell; Richa Agarwala; Alejandro A Schäffer Journal: BMC Med Genet Date: 2010-05-02 Impact factor: 2.103
Authors: Tetyana Zayats; Tammy Yanovitch; Rosalind C Creer; George McMahon; Yi-Ju Li; Terri L Young; Jeremy A Guggenheim Journal: Mol Vis Date: 2009-01-26 Impact factor: 2.367