| Literature DB >> 17723300 |
Jonathan R Young1, Ronsar Eid, Cherilyn Turner, Robert J DeVita, Marc M Kurtz, Kwei-Lan C Tsao, Gary G Chicchi, Alan Wheeldon, Emma Carlson, Sander G Mills.
Abstract
The preparation and structure-activity-relationships of novel pyrrolidine-carboxamides and oxadiazoles are described. Compounds in this series were found to be potent hNK(1) antagonists in vitro and efficacious in vivo with minimal interactions with P(450) liver enzymes. Oxadiazole analog 22 was determined to have excellent hNK(1) binding affinity, functional activity, and a good PD response in vivo.Entities:
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Year: 2007 PMID： 17723300 DOI： 10.1016/j.bmcl.2007.08.028
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823