| Literature DB >> 17723299 |
Peter Jan Zimmermann1, Wilm Buhr, Christof Brehm, Andreas Marc Palmer, Martin Philipp Feth, Jörg Senn-Bilfinger, Wolfgang-Alexander Simon.
Abstract
A series of novel 8-indanylamino- and 8-indanyloxy-substituted imidazo[1,2-a]pyridines with reduced lipophilicity was synthesized from easily accessible starting compounds. The anti-secretory activity of these compounds has been assessed in a competitive binding assay against H(+)/K(+)-ATPase from hog gastric mucosa. Some of the compounds proved to be potent inhibitors of the gastric acid pump.Entities:
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Year: 2007 PMID： 17723299 DOI： 10.1016/j.bmcl.2007.08.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823