Literature DB >> 17723296

Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists.

John A Wendt1, Susan D Deeter, Susan E Bove, Christopher S Knauer, Rachel M Brooker, Corinne E Augelli-Szafran, Roy D Schwarz, Jack J Kinsora, Kenneth S Kilgore.   

Abstract

A novel series of potent 2-aryl pyrido[2,3-d]pyrimidine mGlu5 receptor antagonists are described. The synthesis and pharmacological activities of these analogs are discussed.

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Year:  2007        PMID: 17723296     DOI: 10.1016/j.bmcl.2007.07.047

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.

Authors:  Peng Zhang; Mu-Fa Zou; Alice L Rodriguez; P Jeffrey Conn; Amy Hauck Newman
Journal:  Bioorg Med Chem       Date:  2010-03-27       Impact factor: 3.641

  1 in total

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