Literature DB >> 17721609

Regulation of hyaluronan synthesis by vasodilatory prostaglandins. Implications for atherosclerosis.

Jens W Fischer1, Karsten Schrör.   

Abstract

Hyaluronan (HA) is a macromolecular polysaccharide of the vascular extracellular matrix that confers both structural functions as well as signalling activity. HA is involved in a wide variety of biological processes, such as tissue morphogenesis, malignant growth and metastasis, wound healing and angiogenesis. In atherosclerosis, HA associates with leukocytes and vascular smooth muscle cells (VSMC) and is involved in vascular remodelling. HA is synthesized at the plasma membrane by three HA-synthase isoforms (HAS1-3). Human VSMC upregulate HAS1 and HAS2 in response to prostaglandins via Gs-coupled prostaglandin receptor subtypes IP and EP2. This review discusses the regulation of HA-synthesis by prostaglandins and the evidence for a central role of cyclooxygenase-2/PGE2 in regulation of HA-synthesis during atherogenesis.

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Year:  2007        PMID： 17721609

Source DB:  PubMed          Journal:  Thromb Haemost        ISSN： 0340-6245            Impact factor:   5.249


  19 in total

1.  Microsomal Prostaglandin E Synthase-1 Expression by Aortic Smooth Muscle Cells Attenuates the Differentiated Phenotype.

Authors:  Oreoluwa O Adedoyin; Charles D Loftin
Journal:  J Cardiovasc Pharmacol       Date:  2016-08       Impact factor: 3.105

2.  Hyaluronan deposition and correlation with inflammation in a murine ovalbumin model of asthma.

Authors:  Georgiana Cheng; Shadi Swaidani; Manisha Sharma; Mark E Lauer; Vincent C Hascall; Mark A Aronica
Journal:  Matrix Biol       Date:  2011-01-18       Impact factor: 11.583

3.  NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis.

Authors:  Aleksandr E Vendrov; Nageswara R Madamanchi; Xi-Lin Niu; Kimberly C Molnar; Mason Runge; Cédric Szyndralewiez; Patrick Page; Marschall S Runge
Journal:  J Biol Chem       Date:  2010-06-17       Impact factor: 5.157

4.  Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease.

Authors:  Naxin Guo; Carolyn J Baglole; Charles W O'Loughlin; Steven E Feldon; Richard P Phipps
Journal:  J Biol Chem       Date:  2010-03-22       Impact factor: 5.157

5.  Endothelin-1, the unfolded protein response, and persistent inflammation: role of pulmonary artery smooth muscle cells.

Authors:  Michael E Yeager; Dmitry D Belchenko; Cecilia M Nguyen; Kelley L Colvin; D Dunbar Ivy; K R Stenmark
Journal:  Am J Respir Cell Mol Biol       Date:  2012-01       Impact factor: 6.914

Review 6.  Hyaluronan as an immune regulator in human diseases.

Authors:  Dianhua Jiang; Jiurong Liang; Paul W Noble
Journal:  Physiol Rev       Date:  2011-01       Impact factor: 37.312

7.  The malignant phenotype of breast cancer cells is reduced by COX-2 silencing.

Authors:  Ioannis Stasinopoulos; Noriko Mori; Zaver M Bhujwalla
Journal:  Neoplasia       Date:  2008-11       Impact factor: 5.715

8.  Correlation of hyaluronan deposition with infiltration of eosinophils and lymphocytes in a cockroach-induced murine model of asthma.

Authors:  Georgiana Cheng; Shadi Swaidani; Manisha Sharma; Mark E Lauer; Vincent C Hascall; Mark A Aronica
Journal:  Glycobiology       Date:  2012-08-23       Impact factor: 4.313

Review 9.  Hyaluronan as a therapeutic target in human diseases.

Authors:  Jiurong Liang; Dianhua Jiang; Paul W Noble
Journal:  Adv Drug Deliv Rev       Date:  2015-11-02       Impact factor: 15.470

10.  Synthesis of hyaluronan in oesophageal cancer cells is uncoupled from the prostaglandin-cAMP pathway.

Authors:  S Twarock; K Röck; M Sarbia; A A Weber; R U Jänicke; J W Fischer
Journal:  Br J Pharmacol       Date:  2009-03-26       Impact factor: 8.739
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