| Literature DB >> 17721431 |
Tracy Vargo-Gogola1, Jeffrey M Rosen.
Abstract
Breast cancer is not a single disease, but is instead a collection of diseases that have distinct histopathological features, genetic and genomic variability, and diverse prognostic outcomes. Thus, no individual model would be expected to completely recapitulate this complex disease. Here, the models commonly used to investigate breast cancer including cell lines, xenografts and genetically engineered mice, are discussed to help address the question: what is the most powerful way to investigate this heterogeneous disease?Entities:
Mesh：
Year: 2007 PMID： 17721431 DOI： 10.1038/nrc2193
Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716