Sohela S Hassan1, Kirk R Wilhelmus. 1. Lions Eye Bank of Texas at Baylor College of Medicine, and the Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA.
Abstract
PURPOSE: To identify possible predictors of donor corneal contamination. METHODS: Relationships between eye-banking characteristics of donor corneas and surgical corneoscleral rim culture results were examined in a retrospective case-control study by using logistic regression to estimate odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: Of 263 donor corneal rims, microbial recovery occurred from 23 (9%), including 6 yielding Clostridium perfringens. After adjusting for outdoor temperature and death-to-preservation duration, a positive rim culture occurred more often among tissues having an acceptable but less favorable biomicroscopic rating (OR, 4.22; 95% CI, 1.27-13.98). CONCLUSIONS: This exploratory study suggests that slit-lamp assessment of corneal appearance may correlate with subsequent microbiologic results. Ensuring optimal selection and preservation of the donor cornea may contribute to the safety of eye banking.
PURPOSE: To identify possible predictors of donor corneal contamination. METHODS: Relationships between eye-banking characteristics of donor corneas and surgical corneoscleral rim culture results were examined in a retrospective case-control study by using logistic regression to estimate odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: Of 263 donorcorneal rims, microbial recovery occurred from 23 (9%), including 6 yielding Clostridium perfringens. After adjusting for outdoor temperature and death-to-preservation duration, a positive rim culture occurred more often among tissues having an acceptable but less favorable biomicroscopic rating (OR, 4.22; 95% CI, 1.27-13.98). CONCLUSIONS: This exploratory study suggests that slit-lamp assessment of corneal appearance may correlate with subsequent microbiologic results. Ensuring optimal selection and preservation of the donor cornea may contribute to the safety of eye banking.
Authors: Shahzad I Mian; Anthony J Aldave; Elmer Y Tu; Brandon D Ayres; Bennie H Jeng; Marian S Macsai; Michael L Nordlund; Jeffrey G Penta; Sudeep Pramanik; Loretta B Szczotka-Flynn; Allison R Ayala; Wendi Liang; Maureen G Maguire; Jonathan H Lass Journal: Cornea Date: 2018-09 Impact factor: 2.651
Authors: Efstathia Kiatos; James J Armstrong; Cindy Ml Hutnik; Stephen M Tsioros; Monali S Malvankar-Mehta; William G Hodge Journal: Clinicoecon Outcomes Res Date: 2017-08-09