Literature DB >> 17721005

A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55.

Jun-Ya Ueda1, Takushi Togashi, Susumu Matukura, Aya Nagai, Takuji Nakashima, Hisayuki Komaki, Kozue Anzai, Shigeaki Harayama, Takayuki Doi, Takashi Takahashi, Tohru Natsume, Yasutomo Kisu, Naoki Goshima, Nobuo Nomura, Motoki Takagi, Kazuo Shin-Ya.   

Abstract

A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A(1) and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of beta-arrestin in HeLa cells at the concentration of 20 microM.

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Year:  2007        PMID: 17721005     DOI: 10.1038/ja.2007.59

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  3 in total

Review 1.  The unique chemistry and biology of the piericidins.

Authors:  Xuefeng Zhou; William Fenical
Journal:  J Antibiot (Tokyo)       Date:  2016-06-15       Impact factor: 2.649

Review 2.  Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review.

Authors:  Rui Pan; Xuelian Bai; Jianwei Chen; Huawei Zhang; Hong Wang
Journal:  Front Microbiol       Date:  2019-02-26       Impact factor: 5.640

3.  Cytotoxic Minor Piericidin Derivatives from the Actinomycete Strain Streptomyces psammoticus SCSIO NS126.

Authors:  Kunlong Li; Ziqi Su; Yongli Gao; Xiuping Lin; Xiaoyan Pang; Bin Yang; Huaming Tao; Xiaowei Luo; Yonghong Liu; Xuefeng Zhou
Journal:  Mar Drugs       Date:  2021-07-28       Impact factor: 5.118

  3 in total

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