Literature DB >> 17720904

A single nucleotide polymorphism in the DNA polymerase gamma gene of Saccharomyces cerevisiae laboratory strains is responsible for increased mitochondrial DNA mutability.

Enrico Baruffini1, Tiziana Lodi, Cristina Dallabona, Françoise Foury.   

Abstract

In the Saccharomyces cerevisiae strains used for genome sequencing and functional analysis, the mitochondrial DNA replicase Mip1p contains a single nucleotide polymorphism changing the strictly conserved threonine 661 to alanine. This substitution is responsible for the increased rate of mitochondrial DNA point mutations and deletions in these strains.

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Year:  2007        PMID: 17720904      PMCID: PMC2034627          DOI: 10.1534/genetics.107.079293

Source DB:  PubMed          Journal:  Genetics        ISSN: 0016-6731            Impact factor:   4.562


  22 in total

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