High total dose 5-fluorouracil treatment during pregnancy.

Experience with systemic chemotherapy in the treatment of the pregnant patient with metastatic breast cancer is limited. Most available reports review the use of single agents and those of combination chemotherapy deal predominantly with hematologic malignancies. While 5-fluorouracil (5-FU) is a commonly used antineoplastic agent in the treatment of metastatic breast cancer, there is minimal reported experience with this drug in the therapy of pregnant patients. We report here the birth of a normal infant in a woman with metastatic breast cancer treated with cyclophosphamide, adriamycin and high total dose 5-FU.