UNLABELLED: Collagenous colitis (CC), a form of microscopic colitis, is characterized by a thick subepithelial collagen layer in the colon in the presence of chronic nonbloody watery diarrhoea and macroscopically normal-appearing colonic mucosa. Typically affecting elderly adults, CC is rare in children with only 12 cases previously reported in the literature. We report the case of a 4-year-old girl with CC associated with eosinophilic gastritis, which was clinically responsive to treatment with ketotifen, a benzocycloheptathiophene derivative, and H(1) class of antihistamine that stabilizes mast cells and potentially impairs eosinophil migration to target organs. We review the published cases of paediatric-onset CC and summarize the links between eosinophils and CC in the clinical and basic science literature. CONCLUSION: CC is a rare cause of chronic diarrhoea in children and may relate to mast cell and eosinophil activity.
UNLABELLED: Collagenous colitis (CC), a form of microscopic colitis, is characterized by a thick subepithelial collagen layer in the colon in the presence of chronic nonbloody watery diarrhoea and macroscopically normal-appearing colonic mucosa. Typically affecting elderly adults, CC is rare in children with only 12 cases previously reported in the literature. We report the case of a 4-year-old girl with CC associated with eosinophilic gastritis, which was clinically responsive to treatment with ketotifen, a benzocycloheptathiophene derivative, and H(1) class of antihistamine that stabilizes mast cells and potentially impairs eosinophil migration to target organs. We review the published cases of paediatric-onset CC and summarize the links between eosinophils and CC in the clinical and basic science literature. CONCLUSION: CC is a rare cause of chronic diarrhoea in children and may relate to mast cell and eosinophil activity.
Authors: Eefje M Dons; Gabriel J Echeverri; Lora H Rigatti; Edwin Klein; Claudia Montoya; Roman F Wolf; Jan N M Ijzermans; David K C Cooper; Robert Wagner Journal: Inflamm Bowel Dis Date: 2012-01-31 Impact factor: 5.325
Authors: Johan Bohr; Anna Wickbom; Agnes Hegedus; Nils Nyhlin; Elisabeth Hultgren Hörnquist; Curt Tysk Journal: Clin Exp Gastroenterol Date: 2014-08-21