Literature DB >> 17716834

Transposable element fragments in protein-coding regions and their contributions to human functional proteins.

Ming Wu1, Li Li, Zhirong Sun.   

Abstract

Transposable elements (TEs) and their contributions to protein-coding regions are of particular interest. Here we searched for TE fragments in Homo sapiens at both the transcript and protein levels. We found evidence in support of TE exonization and its association with alternative splicing. Despite recent findings that long evolutionary times are required to incorporate TE into proteins, we found many functional proteins with translated TE cassettes derived from young TEs. Analyses of two Bcl-family proteins and Alu-encoded segments suggest the coding and functional potential of TE sequences.

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Year:  2007        PMID： 17716834     DOI： 10.1016/j.gene.2007.07.012

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  13 in total

Review 1.  The role of Alu elements in the cis-regulation of RNA processing.

Authors:  Chammiran Daniel; Mikaela Behm; Marie Öhman
Journal:  Cell Mol Life Sci       Date:  2015-07-30       Impact factor: 9.261

2.  A human-specific de novo protein-coding gene associated with human brain functions.

Authors:  Chuan-Yun Li; Yong Zhang; Zhanbo Wang; Yan Zhang; Chunmei Cao; Ping-Wu Zhang; Shu-Juan Lu; Xiao-Mo Li; Quan Yu; Xiaofeng Zheng; Quan Du; George R Uhl; Qing-Rong Liu; Liping Wei
Journal:  PLoS Comput Biol       Date:  2010-03-26       Impact factor: 4.475

3.  The contribution of transposable elements to expressed coding sequence in Arabidopsis thaliana.

Authors:  Steven Lockton; Brandon S Gaut
Journal:  J Mol Evol       Date:  2009-01-03       Impact factor: 2.395

4.  Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing.

Authors:  Mari Sepp; Kaja Kannike; Ave Eesmaa; Mari Urb; Tõnis Timmusk
Journal:  PLoS One       Date:  2011-07-15       Impact factor: 3.240

5.  Mobile DNA and the TE-Thrust hypothesis: supporting evidence from the primates.

Authors:  Keith R Oliver; Wayne K Greene
Journal:  Mob DNA       Date:  2011-05-31

6.  Genome-wide survey of ds exonization to enrich transcriptomes and proteomes in plants.

Authors:  Li-Yu Daisy Liu; Yuh-Chyang Charng
Journal:  Evol Bioinform Online       Date:  2012-10-08       Impact factor: 1.625

7.  Transcriptome-wide expansion of non-coding regulatory switches: evidence from co-occurrence of Alu exonization, antisense and editing.

Authors:  Amit K Mandal; Rajesh Pandey; Vineet Jha; Mitali Mukerji
Journal:  Nucleic Acids Res       Date:  2013-01-08       Impact factor: 16.971

Review 8.  Great exaptations.

Authors:  Kathleen H Burns; Jef D Boeke
Journal:  J Biol       Date:  2008

9.  Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus.

Authors:  Larry J Dishaw; M Gail Mueller; Natasha Gwatney; John P Cannon; Robert N Haire; Ronda T Litman; Chris T Amemiya; Tatsuya Ota; Lee Rowen; Gustavo Glusman; Gary W Litman
Journal:  BMC Genet       Date:  2008-12-01       Impact factor: 2.797

10.  Adaptive Evolution Coupled with Retrotransposon Exaptation Allowed for the Generation of a Human-Protein-Specific Coding Gene That Promotes Cancer Cell Proliferation and Metastasis in Both Haematological Malignancies and Solid Tumours: The Extraordinary Case of MYEOV Gene.

Authors:  Spyros I Papamichos; Dimitrios Margaritis; Ioannis Kotsianidis
Journal:  Scientifica (Cairo)       Date:  2015-10-19
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