UNLABELLED: Increased vascular permeability is the main aetiology for hypovolaemic shock and circulatory failure in dengue haemorrhagic fever (DHF). AIM: To investigate the role of vascular endothelial growth factor (VEGF) in the pathogenesis of DHF. METHODS: Serum samples from 41 patients [15 dengue fever (DF), 26 DHF] with serologically confirmed dengue virus infection during the febrile, toxic, convalescent stages and at follow-up were analysed for VEGF. Plasma samples from an additional 27 children (16 DF and 11 DHF) during the febrile, toxic stages and at 4-week follow-up and from eight healthy controls were analysed for VEGF. RESULTS: Serum and plasma VEGF levels were not elevated during the febrile or toxic stages of dengue virus infection and did not differ between patients with DF and DHF. CONCLUSION: Plasma leakage in patients with DHF cannot be explained by elevation of VEGF during the toxic stage of the illness.
UNLABELLED: Increased vascular permeability is the main aetiology for hypovolaemic shock and circulatory failure in dengue haemorrhagic fever (DHF). AIM: To investigate the role of vascular endothelial growth factor (VEGF) in the pathogenesis of DHF. METHODS: Serum samples from 41 patients [15 dengue fever (DF), 26 DHF] with serologically confirmed dengue virus infection during the febrile, toxic, convalescent stages and at follow-up were analysed for VEGF. Plasma samples from an additional 27 children (16 DF and 11 DHF) during the febrile, toxic stages and at 4-week follow-up and from eight healthy controls were analysed for VEGF. RESULTS: Serum and plasma VEGF levels were not elevated during the febrile or toxic stages of dengue virus infection and did not differ between patients with DF and DHF. CONCLUSION: Plasma leakage in patients with DHF cannot be explained by elevation of VEGF during the toxic stage of the illness.
Authors: Oscar Del Moral-Hernández; Norma E Martínez-Hernández; Manuel A Mosso-Pani; Daniel Hernández-Sotelo; Berenice Illades-Aguiar; Eugenia Flores-Alfaro; Verónica Antonio-Vejar; Marco Antonio Leyva-Vázquez Journal: Int J Clin Exp Med Date: 2014-02-15
Authors: Heather M Lander; Ashley M Grant; Thomas Albrecht; Terence Hill; Clarence J Peters Journal: Am J Trop Med Hyg Date: 2014-04-07 Impact factor: 2.345
Authors: Meta Michels; André J A M van der Ven; Kis Djamiatun; Rob Fijnheer; Philip G de Groot; Arjan W Griffioen; Silvie Sebastian; Sultana M H Faradz; Quirijn de Mast Journal: Am J Trop Med Hyg Date: 2012-09-04 Impact factor: 2.345
Authors: Julia N A Mangione; Nguyen Tien Huy; Nguyen Thi Phuong Lan; Evaristus Chibunna Mbanefo; Tran Thi Ngoc Ha; Lam Quoc Bao; Cao Thi Phi Nga; Vo Van Tuong; Tran Van Dat; Tran Thi Thuy; Ha Manh Tuan; Vu Thi Que Huong; Kenji Hirayama Journal: Trop Med Health Date: 2014-07-31