| Literature DB >> 17715930 |
Sarah Sulzer-Mossé1, Matthieu Tissot, Alexandre Alexakis.
Abstract
Chiral amines catalyze the enantioselective conjugate addition of aldehydes to vinyl phosphonates in high yields and with enantioselectivities up to 97% ee. This novel process provides synthetically useful chiral gamma-geminal phosphonate aldehydes which can be easily converted in a few steps into chiral beta-substituted vinyl phosphonates with conservation of the optical purity.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17715930 DOI： 10.1021/ol7015498
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005