Literature DB >> 17715219

Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis.

Changying Jiang1, Ying T Hwang, Guangliang Wang, John C W Randell, Donald M Coen, Charles B C Hwang.   

Abstract

Herpes simplex virus mutants with single substitutions that decrease DNA binding by the DNA polymerase processivity subunit UL42 are only modestly impaired for viral replication. In this study, recombinant viruses harboring two or four of these mutations were constructed. The more substitutions, the more severe the defects in viral replication and DNA synthesis, suggesting that DNA binding by UL42 is important for these processes.

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Year:  2007        PMID： 17715219      PMCID： PMC2168780          DOI： 10.1128/JVI.01133-07

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  15 in total

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Authors:  M M Hingorani; M O'Donnell
Journal:  Curr Biol       Date:  2000-01-13       Impact factor: 10.834

2.  The herpes simplex virus processivity factor, UL42, binds DNA as a monomer.

Authors:  John C W Randell; Donald M Coen
Journal:  J Mol Biol       Date:  2004-01-09       Impact factor: 5.469

3.  Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication.

Authors:  Changying Jiang; Ying T Hwang; John C W Randell; Donald M Coen; Charles B C Hwang
Journal:  J Virol       Date:  2007-01-17       Impact factor: 5.103

4.  Identification of the herpes simplex virus DNA polymerase gene.

Authors:  D J Purifoy; R B Lewis; K L Powell
Journal:  Nature       Date:  1977-10-13       Impact factor: 49.962

5.  The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity.

Authors:  J Gottlieb; A I Marcy; D M Coen; M D Challberg
Journal:  J Virol       Date:  1990-12       Impact factor: 5.103

6.  Identification of the gene encoding the 65-kilodalton DNA-binding protein of herpes simplex virus type 1.

Authors:  D S Parris; A Cross; L Haarr; A Orr; M C Frame; M Murphy; D J McGeoch; H S Marsden
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

7.  A temperature-sensitive mutation in a herpes simplex virus type 1 gene required for viral DNA synthesis maps to coordinates 0.609 through 0.614 in UL.

Authors:  M E Marchetti; C A Smith; P A Schaffer
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

8.  Interaction of herpes simplex virus type 1 DNA polymerase and the UL42 accessory protein with a model primer template.

Authors:  J Gottlieb; M D Challberg
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

9.  Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype.

Authors:  P A Johnson; M G Best; T Friedmann; D S Parris
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103

10.  Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8.

Authors:  Travis J Taylor; David M Knipe
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103
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  8 in total

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Authors:  Changying Jiang; Gloria Komazin-Meredith; Wang Tian; Donald M Coen; Charles B C Hwang
Journal:  J Virol       Date:  2009-05-27       Impact factor: 5.103

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Authors:  Gualtiero Alvisi; Daniela Martino Roth; Daria Camozzi; Gregory S Pari; Arianna Loregian; Alessandro Ripalti; David A Jans
Journal:  J Virol       Date:  2009-07-01       Impact factor: 5.103

4.  Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells.

Authors:  Elisa Sinigalia; Gualtiero Alvisi; Beatrice Mercorelli; Donald M Coen; Gregory S Pari; David A Jans; Alessandro Ripalti; Giorgio Palù; Arianna Loregian
Journal:  J Virol       Date:  2008-10-08       Impact factor: 5.103

5.  Herpes simplex virus 1 DNA polymerase processivity factor UL42 inhibits TNF-α-induced NF-κB activation by interacting with p65/RelA and p50/NF-κB1.

Authors:  Jie Zhang; Shuai Wang; Kezhen Wang; Chunfu Zheng
Journal:  Med Microbiol Immunol       Date:  2013-05-01       Impact factor: 3.402

Review 6.  Herpes simplex viruses: mechanisms of DNA replication.

Authors:  Sandra K Weller; Donald M Coen
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-09-01       Impact factor: 10.005

7.  Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract.

Authors:  Joshua T Schiffer; David Swan; Ramzi Al Sallaq; Amalia Magaret; Christine Johnston; Karen E Mark; Stacy Selke; Negusse Ocbamichael; Steve Kuntz; Jia Zhu; Barry Robinson; Meei-Li Huang; Keith R Jerome; Anna Wald; Lawrence Corey
Journal:  Elife       Date:  2013-04-16       Impact factor: 8.140

8.  The Context-Dependence of Mutations: A Linkage of Formalisms.

Authors:  Frank J Poelwijk; Vinod Krishna; Rama Ranganathan
Journal:  PLoS Comput Biol       Date:  2016-06-23       Impact factor: 4.475
  8 in total

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