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Literature DB >> 17714763

High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old age.

Diana G Taekema¹, Rudi G J Westendorp, Marijke Frölich, Jacobijn Gussekloo.

Abstract

Increased signaling of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) elicits apoptosis of skeletal muscle cells in various animal models. Within a population-based prospective follow up study of elderly people aged 85 years we show that a high innate production capacity of TNF-alpha precedes a steeper decline in muscle strength over time.

Entities: Gene Species

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Year: 2007 PMID： 17714763 DOI： 10.1016/j.mad.2007.07.001

Source DB: PubMed Journal: Mech Ageing Dev ISSN： 0047-6374 Impact factor: 5.432

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Cited

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High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old age.

1. Inflammatory Cytokines and Comorbidity Development in Breast Cancer Survivors Versus Noncancer Controls: Evidence for Accelerated Aging?

2. Associations between inflammatory markers, candidate polymorphisms and physical performance in older Danish twins.

Review 3. Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer.

4. Regenerative potential of human muscle stem cells in chronic inflammation.

5. Relationship between poor physical function, inflammatory markers, and comorbidities in HIV-infected women on antiretroviral therapy.

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7. Serum triiodothyronine levels and inflammatory cytokine production capacity.

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