Literature DB >> 17714708

Cardiac mitochondrial ATP-sensitive potassium channel is activated by nitric oxide in vitro.

Marko Ljubkovic1, Yang Shi, Qunli Cheng, Zeljko Bosnjak, Ming Tao Jiang.   

Abstract

Previous observations on the activation of the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) by nitric oxide (NO) in myocardial preconditioning were based on indirect evidence. In this study, we have investigated the direct effect of NO on the rat cardiac mitoK(ATP) after reconstitution of the inner mitochondrial membranes into lipid bilayers. We found that the mitoK(ATP) was activated by exogenous NO donor S-nitroso-N-acetyl penicillamine or PAPA NONOate. This activation was inhibited by mitoK(ATP) blockers 5-hydroxydecanoate or glibenclamide. Our observations confirm that NO can directly activate the cardiac mitoK(ATP), which may underlie its contribution to myocardial preconditioning.

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Year:  2007        PMID： 17714708     DOI： 10.1016/j.febslet.2007.07.071

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Redox regulation of the mitochondrial K(ATP) channel in cardioprotection.

Authors:  Bruno B Queliconi; Andrew P Wojtovich; Sergiy M Nadtochiy; Alicia J Kowaltowski; Paul S Brookes
Journal:  Biochim Biophys Acta       Date:  2010-11-20

Review 2.  S-glutathionylation of ion channels: insights into the regulation of channel functions, thiol modification crosstalk, and mechanosensing.

Authors:  Yang Yang; Xin Jin; Chun Jiang
Journal:  Antioxid Redox Signal       Date:  2013-08-20       Impact factor: 8.401

3.  Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.

Authors:  Garrett J Gross; Anna Hsu; Adam W Pfeiffer; Kasem Nithipatikom
Journal:  J Mol Cell Cardiol       Date:  2013-02-16       Impact factor: 5.000

4.  Angiotensin-(1-7) increases neuronal potassium current via a nitric oxide-dependent mechanism.

Authors:  Rui-Fang Yang; Jing-Xiang Yin; Yu-Long Li; Matthew C Zimmerman; Harold D Schultz
Journal:  Am J Physiol Cell Physiol       Date:  2010-10-27       Impact factor: 4.249

Review 5.  Cardiac NO signalling in the metabolic syndrome.

Authors:  O Pechánová; Z V Varga; M Cebová; Z Giricz; P Pacher; P Ferdinandy
Journal:  Br J Pharmacol       Date:  2014-12-15       Impact factor: 8.739

6.  Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel.

Authors:  Qunli Cheng; Filip Sedlic; Danijel Pravdic; Zeljko J Bosnjak; Wai-Meng Kwok
Journal:  FEBS Lett       Date:  2010-12-13       Impact factor: 4.124

Review 7.  Roles of the nitric oxide signaling pathway in cardiac ischemic preconditioning against myocardial ischemia-reperfusion injury.

Authors:  Punate Weerateerangkul; Siriporn Chattipakorn; Nipon Chattipakorn
Journal:  Med Sci Monit       Date:  2011-02

Review 8.  Modulation of Potassium Channel Activity in the Balance of ROS and ATP Production by Durum Wheat Mitochondria-An Amazing Defense Tool Against Hyperosmotic Stress.

Authors:  Daniela Trono; Maura N Laus; Mario Soccio; Michela Alfarano; Donato Pastore
Journal:  Front Plant Sci       Date:  2015-12-01       Impact factor: 5.753

Review 9.  Connexins and Nitric Oxide Inside and Outside Mitochondria: Significance for Cardiac Protection and Adaptation.

Authors:  Maria Shvedova; Yana Anfinogenova; Sergey V Popov; Dmitriy N Atochin
Journal:  Front Physiol       Date:  2018-05-16       Impact factor: 4.566

Review 10.  Gas Signaling Molecules and Mitochondrial Potassium Channels.

Authors:  Agnieszka Walewska; Adam Szewczyk; Piotr Koprowski
Journal:  Int J Mol Sci       Date:  2018-10-18       Impact factor: 5.923
  10 in total

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