| Literature DB >> 17714648 |
Jerome Korzelius1, Sander van den Heuvel.
Abstract
All eukaryotes use multiple controls to restrict DNA replication to once per cell cycle. Nevertheless, inactivation of a single gene, cul-4, causes massive re-replication in Caenorhabditis elegans. A novel study explains this dramatic phenotype by demonstrating that the CUL-4 E3 ligase simultaneously controls two critical licensing factors: CDT-1 and CDC-6.Entities:
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Year: 2007 PMID： 17714648 DOI： 10.1016/j.cub.2007.06.029
Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834