OBJECTIVE: Dementia occurs frequently in patients with Parkinson's disease (PD). However, the nature of the dementing process remains controversial. We evaluated various cognitive functions in patients with PD, compared fractional anisotropy (FA) values between PD patients with and without dementia. METHODS: Thirty-seven consecutive patients with Hoehn-Yahr stage III or IV PD participated in this study. Patients were divided into two groups: (i) PD with dementia group (PDD) and (ii) PD without dementia group (PDND). There were 11 PDD and 26 PDND cases. Ten controls were also studied. RESULTS: The PDD group showed significant FA reduction in the bilateral posterior cingulate bundles compared with PDND. FA values in the left posterior cingulate bundle showed significant correlations with many cognitive parameters. INTERPRETATION: Our results showed that the posterior cingulate areas play some important roles in the dementing process in PDD. However, as the pathological processes responsible for dementia in PD patients may be multifaceted, further studies are necessary.
OBJECTIVE:Dementia occurs frequently in patients with Parkinson's disease (PD). However, the nature of the dementing process remains controversial. We evaluated various cognitive functions in patients with PD, compared fractional anisotropy (FA) values between PDpatients with and without dementia. METHODS: Thirty-seven consecutive patients with Hoehn-Yahr stage III or IV PD participated in this study. Patients were divided into two groups: (i) PD with dementia group (PDD) and (ii) PD without dementia group (PDND). There were 11 PDD and 26 PDND cases. Ten controls were also studied. RESULTS: The PDD group showed significant FA reduction in the bilateral posterior cingulate bundles compared with PDND. FA values in the left posterior cingulate bundle showed significant correlations with many cognitive parameters. INTERPRETATION: Our results showed that the posterior cingulate areas play some important roles in the dementing process in PDD. However, as the pathological processes responsible for dementia in PDpatients may be multifaceted, further studies are necessary.
Authors: Mohammad Haris; Anup Singh; Kejia Cai; Christos Davatzikos; John Q Trojanowski; Elias R Melhem; Christopher M Clark; Arijitt Borthakur Journal: J Neurol Date: 2010-10-07 Impact factor: 4.849
Authors: Xu Chen; Bhargav Errangi; Longchuan Li; Matthew F Glasser; Lars T Westlye; Anders M Fjell; Kristine B Walhovd; Xiaoping Hu; James G Herndon; Todd M Preuss; James K Rilling Journal: Neurobiol Aging Date: 2013-04-24 Impact factor: 4.673
Authors: K Kamagata; Y Motoi; O Abe; K Shimoji; M Hori; A Nakanishi; T Sano; R Kuwatsuru; S Aoki; N Hattori Journal: AJNR Am J Neuroradiol Date: 2012-01-12 Impact factor: 3.825