OBJECTIVES: To obtain data on long-term mortality among young ischemic stroke patients compared with controls in this population-based study. MATERIAL AND METHODS: We used Kaplan-Meier survival analysis to compare 232 patients aged 15-49 years with first-ever cerebral infarction in 1988-1997 and 453 controls followed from inclusion to death or 1 August 2005 for 2515 and 5558 person-years respectively. In a subanalysis of 192 patients, we compared risk factor variables using the Kaplan-Meier method and log-rank testing. We applied a Cox proportional hazards model to adjust for multiple risk factors. RESULTS: Forty-five patients and nine controls died during follow-up (P < 0.0005). Independent risk factors for mortality were active tumor disease (P < 0.0005), high consumption of alcohol (P < 0.0005), coronary atherosclerosis (P < 0.001), living alone (P < 0.02), seizures (P < 0.04) and smoking (P = 0.08). CONCLUSIONS: Long-term mortality was significantly increased among young stroke patients, mainly due to such lifestyle factors as high consumption of alcohol and tobacco.
OBJECTIVES: To obtain data on long-term mortality among young ischemicstrokepatients compared with controls in this population-based study. MATERIAL AND METHODS: We used Kaplan-Meier survival analysis to compare 232 patients aged 15-49 years with first-ever cerebral infarction in 1988-1997 and 453 controls followed from inclusion to death or 1 August 2005 for 2515 and 5558 person-years respectively. In a subanalysis of 192 patients, we compared risk factor variables using the Kaplan-Meier method and log-rank testing. We applied a Cox proportional hazards model to adjust for multiple risk factors. RESULTS: Forty-five patients and nine controls died during follow-up (P < 0.0005). Independent risk factors for mortality were active tumor disease (P < 0.0005), high consumption of alcohol (P < 0.0005), coronary atherosclerosis (P < 0.001), living alone (P < 0.02), seizures (P < 0.04) and smoking (P = 0.08). CONCLUSIONS: Long-term mortality was significantly increased among young strokepatients, mainly due to such lifestyle factors as high consumption of alcohol and tobacco.
Authors: Stefan Greisenegger; Sonja Zehetmayer; Julia Ferrari; Wilfried Lang; Johanna Fizek; Eduard Auff; Wolfgang Lalouschek; Wolfgang Serles Journal: J Neurol Date: 2011-02-01 Impact factor: 4.849
Authors: Merel Sanne Ekker; Jamie Inge Verhoeven; Ilonca Vaartjes; Wilhelmus Martinus Tim Jolink; Catharina Johanna Maria Klijn; Frank-Erik de Leeuw Journal: JAMA Date: 2019-06-04 Impact factor: 56.272
Authors: Qianwen Zheng; Yawen Li; Lu Zhang; Qiang Yao; Jing Zhang; Mier Li; Ju Wang; Cairong Zhu Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2019-04-30
Authors: Noortje A M M Maaijwee; Loes C A Rutten-Jacobs; Pauline Schaapsmeerders; Ewoud J van Dijk; Frank-Erik de Leeuw Journal: Nat Rev Neurol Date: 2014-04-29 Impact factor: 42.937