PURPOSE: In this study, we propose the existence of a relationship between cardiac myxomas and the immunologic features or interleukin-6 (IL-6), while also considering the optimal treatment of cardiac myxoma, especially "familial myxoma." METHODS: In a 19-year period at our hospital, 20 patients underwent 21 operations for cardiac myxomas. The immunologic features and the IL-6 levels were measured pre-operatively in 13 cases and post-operatively in 10 cases. A case of "familial myxoma" was diagnosed based on molecular genetic analyses. RESULTS: No patients died in the hospital. The tumor size correlated with the preoperative IL-6 and/or alpha1-globulin values (P < 0.05). In addition, all of the immunologic features and IL-6 levels normalized by 4 weeks after surgery. "Familial myxoma" demonstrated recurrence without showing increases in either the immunologic features, inflammatory signs, or serum IL-6 levels. CONCLUSIONS: Patients with cardiac myxoma should therefore be operated on immediately because the possibility that the tumor size might be large when IL-6 and/or alpha1-globulin values are high. In addition, cases of "familial myxoma" require careful observation and periodic echocardiography after surgery to identify any possible recurrence. Recently, molecular genetic analyses are therefore considered to be an important diagnostic tool for cardiac myxoma, especially "familial myxoma." Our "familial myxoma" case demonstrated a C769T PRKAR1a mutation, which has also been observed in other cases of "familial myxoma."
PURPOSE: In this study, we propose the existence of a relationship between cardiac myxomas and the immunologic features or interleukin-6 (IL-6), while also considering the optimal treatment of cardiac myxoma, especially "familial myxoma." METHODS: In a 19-year period at our hospital, 20 patients underwent 21 operations for cardiac myxomas. The immunologic features and the IL-6 levels were measured pre-operatively in 13 cases and post-operatively in 10 cases. A case of "familial myxoma" was diagnosed based on molecular genetic analyses. RESULTS: No patients died in the hospital. The tumor size correlated with the preoperative IL-6 and/or alpha1-globulin values (P < 0.05). In addition, all of the immunologic features and IL-6 levels normalized by 4 weeks after surgery. "Familial myxoma" demonstrated recurrence without showing increases in either the immunologic features, inflammatory signs, or serum IL-6 levels. CONCLUSIONS:Patients with cardiac myxoma should therefore be operated on immediately because the possibility that the tumor size might be large when IL-6 and/or alpha1-globulin values are high. In addition, cases of "familial myxoma" require careful observation and periodic echocardiography after surgery to identify any possible recurrence. Recently, molecular genetic analyses are therefore considered to be an important diagnostic tool for cardiac myxoma, especially "familial myxoma." Our "familial myxoma" case demonstrated a C769TPRKAR1a mutation, which has also been observed in other cases of "familial myxoma."
Authors: M Casey; C J Vaughan; J He; C J Hatcher; J M Winter; S Weremowicz; K Montgomery; R Kucherlapati; C C Morton; C T Basson Journal: J Clin Invest Date: 2000-09 Impact factor: 14.808
Authors: Alexander Javier Bolanos; George Dibu; Floyd W Burke; Charles T Klodell; Ying Li; Kenneth H Rand; Alexandra Rose Lucas Journal: BMJ Case Rep Date: 2015-10-29
Authors: Andreas Karabinis; George Samanidis; Mazen Khoury; George Stavridis; Konstantinos Perreas Journal: Medicine (Baltimore) Date: 2018-09 Impact factor: 1.817
Authors: Tomás Francisco Cianciulli; Alberto Cozzarin; Juan Bautista Soumoulou; María Cristina Saccheri; Ricardo José Méndez; Martín Alejandro Beck; Juan Alberto Gagliardi; Jorge Alberto Lax Journal: J Cardiovasc Imaging Date: 2019-01