Literature DB >> 17713576

HIPK2: a multitalented partner for transcription factors in DNA damage response and development.

Cinzia Rinaldo1, Andrea Prodosmo, Francesca Siepi, Silvia Soddu.   

Abstract

Protein phosphorylation is a widely diffuse and versatile post-translational modification that controls many cellular processes, from signal transduction to gene transcription. The homeodomain-interacting protein kinases (HIPKs) belong to a new family of serine-threonine kinases first identified as corepressors for homeodomain transcription factors. Different screenings for the identification of new partners of transcription factors have indicated that HIPK2, the best characterized member of the HIPK family, is a multitalented coregulator of an increasing number of transcription factors and cofactors. The aim of this review is to describe the different mechanisms through which HIPK2 regulates gene transcription.

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Year:  2007        PMID： 17713576     DOI： 10.1139/O07-071

Source DB:  PubMed          Journal:  Biochem Cell Biol        ISSN： 0829-8211            Impact factor:   3.626


  52 in total

1.  Homeodomain-interacting protein kinase 2 regulates DNA damage response through interacting with heterochromatin protein 1γ.

Authors:  Y Akaike; Y Kuwano; K Nishida; K Kurokawa; K Kajita; S Kano; K Masuda; K Rokutan
Journal:  Oncogene       Date:  2014-08-25       Impact factor: 9.867

Review 2.  Wnt signaling through T-cell factor phosphorylation.

Authors:  Sergei Y Sokol
Journal:  Cell Res       Date:  2011-05-24       Impact factor: 25.617

3.  HIPK2 is necessary for type I interferon-mediated antiviral immunity.

Authors:  Lili Cao; Guang Yang; Shandian Gao; Chunxia Jing; Ruth R Montgomery; Yuxin Yin; Penghua Wang; Erol Fikrig; Fuping You
Journal:  Sci Signal       Date:  2019-03-19       Impact factor: 8.192

4.  Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain.

Authors:  Antonella Scaglione; Laura Monteonofrio; Giacomo Parisi; Cristina Cecchetti; Francesca Siepi; Cinzia Rinaldo; Alessandra Giorgi; Daniela Verzili; Carlotta Zamparelli; Carmelinda Savino; Silvia Soddu; Beatrice Vallone; Linda Celeste Montemiglio
Journal:  Protein Sci       Date:  2017-12-28       Impact factor: 6.725

5.  High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.

Authors:  Chandrasekhar V Miduturu; Xianming Deng; Nicholas Kwiatkowski; Wannian Yang; Laurent Brault; Panagis Filippakopoulos; Eunah Chung; Qingkai Yang; Juerg Schwaller; Stefan Knapp; Randall W King; Jiing-Dwan Lee; Sanna Herrgard; Patrick Zarrinkar; Nathanael S Gray
Journal:  Chem Biol       Date:  2011-07-29

6.  MUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway.

Authors:  Deepak Raina; Rehan Ahmad; Dongshu Chen; Shailendra Kumar; Surender Kharbanda; Donald Kufe
Journal:  Cancer Biol Ther       Date:  2008-12-09       Impact factor: 4.742

7.  Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival.

Authors:  Cristina Lanni; Lavinia Nardinocchi; Rosa Puca; Serena Stanga; Daniela Uberti; Maurizio Memo; Stefano Govoni; Gabriella D'Orazi; Marco Racchi
Journal:  PLoS One       Date:  2010-04-14       Impact factor: 3.240

8.  Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271.

Authors:  Kensuke Sakamoto; Bo-Wen Huang; Kenta Iwasaki; Kiros Hailemariam; Jun Ninomiya-Tsuji; Yoshiaki Tsuji
Journal:  Mol Biol Cell       Date:  2010-06-23       Impact factor: 4.138

9.  Different functions of HIPK2 and CtBP2 in traumatic brain injury.

Authors:  Feihui Zou; Jian Xu; Hongran Fu; Jianhua Cao; Hui Mao; Mingjie Gong; Gang Cui; Yang Zhang; Wei Shi; Jian Chen
Journal:  J Mol Neurosci       Date:  2012-10-18       Impact factor: 3.444

10.  Cofactor-activated phosphorylation is required for inhibition of cortical neuron differentiation by Groucho/TLE1.

Authors:  Manuel Buscarlet; Robert Hermann; Rita Lo; Yeman Tang; Kerline Joachim; Stefano Stifani
Journal:  PLoS One       Date:  2009-12-01       Impact factor: 3.240
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